My labs came back as this: the 4 markers. Can you tell me what your thoughts are?

New Paid Tier in the Methylation Hub - Paid tier opens tomorrow: recorded sessions plus direct messaging for broad recommendations, not treatment - One-on-one sessions possibly in the future - Priced at 29 USD a month to start, for the first 50 people; annual is 290 USD, saving 2 months' worth - Annual Members get the MTHFR clinician guide (currently 59 USD) free, plus its upcoming upgraded version - Fertility Unasked Questions answered, and Archive foundations content stay free; implementation content moves to paid Over Methylation - Symptoms within days of starting: anxiety, feeling wired, insomnia, palpitations, headaches, irritability - Excess methyl groups build SAME; byproduct SAR inhibits COMT, so dopamine accumulates, worse with slow COMT genetics - Labs: normal homocysteine, high B12 and high folate - Management: pause methyl donors, test potassium to rule out hypokalemia, switch to hydroxy B12, restart methyl folate low and slow Methyl Trapping - Methionine synthase lacks enough B12, so 5-MTHF gets stuck, and homocysteine rises - Labs: normal or high serum folate, high homocysteine, low or low normal active B12, elevated methylmalonic acid - - RBC folate preferred over serum folate - Management: give B12 first, restart methyl folate after a couple of weeks, retest homocysteine Key Takeaways - The difference is B12: one needs B12, the other needs fewer methyl donors - Treat labs combined with genetics, not the MTHFR genotype alone (e.g. homozygous 677, up to 70% slower) - Prefer hydroxy or hydroxy plus adenosylcobalamin over methyl B12 where possible - You can send questions for the next live via DMs or post in the methylation group Q&A section

Saturday recording is here. Today I discussed a case in the order of the Archive, going through the different modules. Case study: 38-year-old woman, wired, anxious, disrupted sleep after starting methylfolate She is Compound Heterozygous: one copy of C677T and one copy of A1298C Your questions are welcome!

Did a supplement ever make you feel worse? Methylfolate that left you wired at 3am. B12 that did nothing. A protocol that worked for your friend and flattened you. Next live, I'm walking one patient through all seven Archive modules to show why that happens. It is rarely the wrong supplement. Usually it is the right one, taken in the wrong order. We'll cover: - Why a "normal" homocysteine of 13 can still mean the cycle is struggling - The folate trap: plenty of folate on paper, cells short of it - How four years on an acid blocker can undo a perfect protocol - The case that plateaued, and where the answer lives in the next release I'll also explain what changes on 1 October. Modules 1–7 stay free, permanently, and the second half of the Archive opens for members. Tell me below: what did you take, and how did you feel? I'll use your stories on the live (anonymously) and answer as many as I can. 📅 Saturday 26 September, 8 PM UK / 3 PM ET / 12 PM PT 🎥 The recording goes into the Archive. Education, not personal medical advice. Dr Jean-Marc

Great news, I just released 4 new modules from the Archive in the Classroom COMT and neurotransmitters Homocysteine Gut Health Why Supplements Can Backfire Let me know what you think; looking forward to hearing from you.😀