Nowhere comfortable to carry your keys and or phone

Your socks slipping down in to your shoes

Chaffing (nipples, arms, thighs) anywhere else ?

Your car seat gets sweaty after a long run

Your running shoes feel worn out to fast

Other runners who don't say hello or wave back when passing by

Sweat dripping down your face and have nothing wipe it off with.

Getting you "new" shoes covered in mud and dirt for the first time

I will add mine in the comments

Talking to people who don't run about running.. (they just can't understand)