Metabolic Therapy Plan for High-Grade and Metastatic Cervical Cancer

Dec '24 (edited) • 📝 Member Journeys & Results

SOC (Standard of Care) alone has not been enough for us. We are now fully into Metabolic Therapy as a complementary treatment.

This plan is based on the hybrid orthomolecular protocol tailored for my mum, who has high-grade, metastatic cervical cancer that has spread to the brain, bones, and lymph nodes. This protocol was developed based on the latest research, insights from our community, and personal experiences. Any suggestions would be appreciated to help further refine this plan.

Please note: Always consult with healthcare professionals before implementing any changes.

Case Overview

Condition: High-grade cervical cancer with brain, bone, and lymph node metastases.
History: Stroke and Pulmonary Embolism: June (on blood thinners since then). Chemotherapy and Immunotherapy: Completed 6 cycles by October. Imaging Results: NED (No Evidence of Disease) after 4 cycles on PET; 25% reduction in brain metastases. However, new brain metastases have appeared in December (likely due to the blood-brain barrier).

Protocol Duration: 12 weeks (regardless of cancer type). Adjustments may be required based on glucose or glutamine-driven cancer types and sensitivity testing.

Testing Recommendations

To ensure the protocol is optimized, the following tests should be conducted:

RGCC: Genetic analysis of cancer cells for personalized treatment recommendations.
Imaging Tests: CSR (Chest Radiograph): Detects lung infections or abnormalities.
Blood Tests: CRP: Detects inflammation or infection. CBP: Screens for anemia, infections, and clotting issues. Vitamin D: Assesses bone health and calcium absorption. ESR: Monitors inflammation or autoimmune conditions. CBC: Diagnoses anemia, infections, or blood disorders.
Organ Function Tests: Kidney Function: Evaluates filtering capabilities. Liver Function: Assesses detoxification and metabolism. Lung Function: Diagnoses asthma, COPD, or fibrosis.
Clotting and Cardiac Markers: Fibrinogen: Evaluates clotting risk. D-dimer: Detects DVT or pulmonary embolism. Troponin: Screens for heart attack.
Gene Testing: Methylation deficiencies (e.g., MTHFR mutations).

Dietary Plan

Strict Carnivore or Keto-Carnivore: Carb Limit: <20g/day. Forbidden: Bread, pasta, rice, potatoes, sweets. Allowed: Honey and berries in moderation.
Meal Supplements: Apple cider vinegar capsules. Berberine. Curcumin. ECGC. Quercetin. Resveratrol. (before meals)

These supplements inhibit glucose and glutamine absorption, crucial for combating gluconeogenesis (the liver’s conversion of proteins and fats to glucose).

Off-Label Medications

Primary Agents: Ivermectin: 1-2mg/kg daily. Mebendazole: 1500mg daily or 50mg/kg (with meals) or Fenbendazole: 1000mg 3x/week. Metformin: Pulsed 3x/week.
Additional Options: Berberine: 300mg per meal (alternative to metformin). Hydroxychloroquine: 200mg daily. Sodium Phenylbutyrate: Pulsed 3x/week. DCA: 333mg pulsed 3x/week (or one week on/one week off). Take with 500mg TUDCA 2x/day to prevent neuropathy.
Glutamine Inhibition: DON: 0.2-0.4 mg/kg on days 0, 2, 4, 6, 8, followed by 2 weeks off.
Alternatives to DON:

Intermittent fasting (16/8 daily).
Hydroxychloroquine, Sodium phenylbutyrate, fenbendazole, EGCG, and berberine to block glutamine pathways.
24-hour dry fast 1x/week.
Matcha green tea or ECGC before meals to inhibit l-glutamine production.

Supplement Protocol

Essential Supplements: Vitamin C (IV): 1.5g/kg 2-3x/week. Vitamin D3 + K2 (MK7): Dosage based on serum levels: 50,000 IU/day if <30ng/mL. 25,000 IU/day for levels 30-60ng/mL. Maintenance: 2000 IU/day. Ultra Omega-3: 500 EPA + 250 DHA daily or 1 tsp cod liver oil. Zinc: 5mg daily (adjust to serum levels). Magnesium: 200mg daily.
Additional Support: Melatonin: 300mg before bed. Turkey Tail Mushrooms: 15-18g/day. Milk Thistle/TUDCA: Liver support. Creatine: 5g/day (muscle health). Resveratrol: 500mg/day.

Adjunct Therapies

Hyperbaric Oxygen Therapy (HBOT): 1.5-2.5 ATA for 45-90 mins, 2-3x/week. Combine with DCA, berberine, fenbendazole, ECGC, and MCT oil.
Infrared Light/Sauna: Stimulates detoxification.
Water Therapies: Hydrogen-infused water or DDW.
Other: Grounding sheets for circulation and sleep. Trampoline for lymphatic stimulation. Weightlifting to prevent cachexia. One dry fasting day per week.

Uncertainties

Probiotics: Potential interactions with immunotherapy.
Blood Thinners: ECGC, curcumin, quercetin, and CBD may interact with rivaroxaban. Monitor closely.
Antioxidants: Vitamin C and E capsules—potentially contraindicated according to Dr. Peavler.
Other Considerations (Research further): Low-dose naltrexone. Iodine. Artemisinin. Ursolic acid (glutamine blocker).

Conclusion

This plan is an integrative, evidence-based approach aimed at targeting multiple cancer pathways while supporting overall health and well-being. Please provide feedback and suggestions to further refine it.

I have created a new category: 'Protocols' - a place for members to share their own protocols.

Update 25/01/2025: To avoid potential interactions and bleeding risks with rivaroxaban, the dose was decreased to 10mg and some off labels and supplements were excluded. Some supplements/off labels need to be spaced out to avoid interactions.

Update 28/01/2025: Considering stopping rivaroxaban to implement the supplements safely and avoid bleeding risks. (Second screenshot)

Update 09/03/2025: Still on rivaroxaban. No longer doing HBOT until absolutely necessary due to theoretical increased risks of blood vessel rupture on the brain. Protocol revised slightly. (Third screenshot.) Pulsing with fenbendazole, artemisinin and EGCG 3x per week (including the other supplements and off-labels as well)

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