If the MOC isn't a technical review this could still have dire consequences when production is established.
1.Pressure-test the technical basis of every change against its protective systems - The question isn't "does this work?" but rather "what does this change isolate, defeat, or bypass?"
2.Put a fresh set of eyes on overpressure protection - Isolation from a PSV is one of the most common and lethal review misses.
3.Don't confuse a thorough process with a thorough analysis - A signed MOC with a flawed hazard review is more dangerous than no MOC, because it creates false confidence.