My current weight loss stack is Retatrutide and Tesamorelin. I want to add Ipamorelin, 5-Amino-1MQ, AOD-964 and maybe Mots-C, but cost is always an issue. If I could only add one or two to my Reta and Tesamorelin stack which would give me the best bang for my weight loss buck? Goal is 150 lb weight loss, so significant.

Can someone give me the dosage for Semax?

My DMs have been flooded all week. "Derek, is this the end?" "Are prices going up?" "Should I stock up?" So I broke it all down: → What 66-80 actually does → How it hits compounding pharmacies (spoiler: it's real) → Why ALL research peptides might see price increases (not just GLP-1s) → The liquidation sales happening right now—and why I don't think 66-80 is the reason → What I'm actually watching over the next few months Short version: I've yet to see anything kill this space. I don't see it happening as fast as everyone's panicking about. But there ARE real implications here. Full breakdown 👇 https://open.substack.com/pub/derekpruski/p/fda-import-alert-66-80-what-it-actually?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Disclaimer: This article is for educational and informational purposes only. All compounds discussed are research use only (RUO) and not approved for human consumption. This content does not constitute medical advice. A common belief in peptide and metabolic research is that oral research methods are ineffective because compounds don’t survive digestion. While this is often true for peptides, it does not apply to every compound discussed in the same space. 5-Amino-1MQ is frequently grouped together with peptides, but from a chemistry standpoint, it behaves very differently. Understanding why requires looking at one key concept: molecular weight, measured in Daltons. Why Dalton Weight Matters The gastrointestinal tract acts like a size filter. Smaller molecules can pass through the intestinal lining more easily, while larger ones struggle to cross intact. In pharmaceutical research, there is a widely accepted guideline: - Compounds under ~500 Daltons are more likely to be absorbed orally - Compounds well above 500 Daltons tend to have poor oral absorption Most peptides fall far above this range, which makes oral research unreliable for them. Why Peptides Usually Need Subcutaneous Research Peptides are long chains of amino acids, which creates two problems in oral research models: 1. They are broken down during digestionThe digestive system is designed to split peptides into individual amino acids, meaning the original structure rarely survives long enough to be absorbed. 2. They are too large to cross the gut lining intactEven if some of the structure remains, peptide size and polarity make it difficult to pass through the intestinal barrier. Because of this, peptide research often relies on subcutaneous (subq) administration to bypass digestive breakdown and size limitations. Why 5-Amino-1MQ Is Different 5-Amino-1MQ is not a peptide. It is a small-molecule compound with a molecular weight in the ~200–300 Dalton range, depending on the form studied.

Happy Holiday's everyone!! We now have gift cards available! https://www.refillpen.com/gift-card We are also running a holiday special! Free bac water box with a black cartridge insert ! With purchases after code of $75 until 12-25-25 choose your color on site. Choose from silk silver, silk purple, silk green or silk red!! Refillpen.com code Derek For research purposes only