I'm an outside-the-box thinking overachiever who likes to push boundaries, so of course I wondered: do peptides REALLY ACTUALLY TRULY degrade, or is that an urban legend? I mean, if the company ships them without ice packs, then why do I need to store them in the freezer? Never really made sense to me. I'm getting closer to the answer. GOOD NEWS! I just discovered some studies on the degradation rates! The studies were done over three months on RECONSTITUTED peptides, comparing refrigerated vs. non-refrigerated. I've attached the available study they conducted for Tesamorelin as an example... AND I've attached a study they did on a sample that got lost in the mail for TWO YEARS! If you go here, you can read the others I've listed in #1 below --> https://peptidecrafters.com/peptide-experiments-studies/ WARNINGS: 1. You do have to get yourself a user account to access the studies. They've done MOTS-C, BPC-157, GLP-1, TB-500, Tesamorelin, NAD+, GHK-CU 2. This is a "shopping" site, so use caution not to get distracted. I can assure you, Diane's prices are far more affordable. The moral of most of these studies is that a reconstituted, refrigerated peptide degrades very little in the first thirty days and declines only marginally in the second month...although the results differed for each specific peptide.