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11 contributions to BIOHACKING | TONY HUGE
My struggle
I've had to take mental health meds to maintain and convince the people that in prison me that I'm okay that I'm not a danger to society the same meds have caused me to gain weight to the point that it affects my self-esteem it affects myself image I'm an ectomorph I've never had trouble with my weight but my weight now affects me negatively so I need help to get back to where I was back to when I liked my own reflection in the mirror?
2 likes • 8d
@Andy McDermott I've dealt with weight gain from medications myself, and I know how frustrating it can be when a treatment helps one part of your life but creates problems elsewhere. One example: I took gabapentin off-label for anxiety for years, and the side effects were awful. I experienced substantial weight gain, brain fog, dizziness, and cognitive difficulties. It took me nearly a year to taper off the medication. Another example is my mood stabilizer. The one I take can cause low sodium, which has been an ongoing concern. But it's the last psychiatric medication standing after eliminating gabapentin and several others, and I consider that a win. Sometimes it really comes down to a risk-versus-benefit analysis. Eventually, I discovered tirzepatide, which made a tremendous difference in my ability to manage my weight, my longstanding binge eating disorder (BED), and the pain and inflammation associated with my osteoarthritis. This is one peptide I intend to remain on indefinitely. Medication-related weight gain isn't necessarily about diet or discipline. Some psychiatric medications can affect appetite, insulin sensitivity, and metabolic regulation. Gabapentin can also contribute to weight gain, although its mechanisms differ. Exercise and nutrition certainly matter, but they don't always overcome medication-related effects. There may be alternatives with fewer metabolic side effects, depending on which medications you're taking. I wouldn't recommend abruptly discontinuing anything, particularly psychiatric medications. A medication review that considers both your mental health and metabolic health may be more useful than simply pushing yourself harder in the gym. I certainly don't believe people should have to accept every adverse effect without exploring their options. And I wouldn't assume that your difficulty managing your weight means you lack discipline. Sometimes there's much more going on physiologically than people realize.
2 likes • 8d
@Andy McDermott I'm glad my experience was helpful! And I'm glad you're finding ways to exercise that work within your circumstances. Just remember to give yourself some credit for what you're already doing. Wishing you the best!
Healthiest supplements to inhibit adverse side effects of MK-677
Hello everyone, I am new to performance enhancing chemicals. What are some real negative side effects that could affect longevity, and what to take with MK to inhibit the side effects.
1 like • 8d
One thing I'd add, if I may, is that MK-677 (ibutamoren) isn't actually a peptide. It's a compound taken by mouth that mimics ghrelin, a hormone involved in hunger and growth hormone release. Essentially, it encourages your body to produce more growth hormone. The effects on blood sugar and metabolism deserve attention, especially for someone new to these compounds. In a randomized human study, researchers found that MK-677 made the body less responsive to insulin, increased blood sugar and appetite, and caused fluid retention. There's also some interesting sleep research. A very small study in older adults reported approximately 50% more REM sleep, but that doesn't establish an effective or safe low-dose sleep protocol. I've spent years researching medical treatments, peptides, and their effects on the body, partly because of my own experiences navigating chronic illnesses. One thing I've learned is that adding another supplement to counteract a medication's side effects might not necessarily be the answer. I haven't come across convincing clinical evidence that supplements marketed for insulin support reliably prevent MK-677's metabolic effects. I'd be more interested in monitoring blood sugar, HbA1c (which reflects average blood sugar over approximately three months), blood pressure, and fluid retention. Those measurements can tell us considerably more about what's happening in the body. MK-677 does increase growth hormone, but whether that translates into better long-term health or longevity hasn't been established.
Complete Blood Work. Any recommendations?
Hello Community, Hope all is well. I am sharing my full bloodwork in the hopes that it inspires others to do the same, get recommendations from the community on what I need to improve and how, and learn how supplements, peptides, sarms, etc… affect us. This is the panel I got and paid for. I’m sure there are some markers that weren't tested and I will try my best to get them tested next time. My goal is to get tested again in the next 8-12 weeks after “working” on what I need to work on. I did a washout for 3-4 weeks, with no peptides, test boosters, and no sarms. I only took (which is still a lot) the things I consider everyday essential and I don’t see a need to stop taking them. Unless the community can convince me they are worthless, not needed, or a waste of money. I am not stubborn and open to all suggestions. The only real red flag is lp(a) so I am planning on taking 10mg of ezetimibe. I heard of testosterone helping to lower lp(a). Morning supps: Daily 250mg tudca 1 gram of vitamin c 1 gram of taurine 600mg of NAC Multivitamin Astragalus root extract 500mg Zinc gluconate 30mg Horny goat weed 1gram (might stop after bottle ends though) Morning Spps: EOD 81mg of aspirin (might stop for awhile) 500 mg of valacyclovir Preworkout: 6 grams of l citrulline 5 grams of glycerol monostearate (65%) 2.5 grams fo betaine anhydrous 7.5 grams of creatine 1 gram of ALCAR 2-3 grams of my own electrolyte mix Sleep + Night Time Stack: Sleep: 5-10mg of melatonin (5x/week) 600 mg ashwagandha ksm-66 (3x/week) 5 mg l-thp (new edition, but it's going to be part of my daily stack) 50 mg trazodone (2-3x/week max) for when i get into the weeks of 5 hours or less sleeping 5 mg seltorexant (2-3x/week max) same reason as trazodone. I will either take this or trazodone, not both. Night stack: 5mg rosuvastatin (4-6x/ week) 5mg tadalafil (5-6x/week) I’ve always had trouble with my sleep and I have sleep apnea (I use cpap) I work out 5 days a week. Push, pull, legs, and cardio (walking or boxing for 10-20 minutes 3-4 times a week)
1 like • 12d
@Edgar Gonzalez Edgar, now that I can relate to! 😂 I'm a longtime member of what I call the 4 A.M. Club, although I'd gladly resign my membership. You can have excellent CPAP numbers and still struggle to get enough hours of sleep. Another wrinkle? Sleep maintenance (staying asleep rather than falling asleep) can involve different mechanisms from those responsible for sleep apnea. So improving one doesn't necessarily fix the other. Seven consistent hours would feel like a luxury to me, too!
1 like • 12d
@Edgar Gonzalez right? I keep trying to give my shirt away but no takers 😜 I’ve not tried trazodone. RX sleep meds never worked. I’m using amino acids now. So far so good 👍
Timing is EVERYTHING
Compounds like BAM-15, SLU-PP-332, 5-AMINO-1MQ, and GW-501516 / CARDARINE all have different half life’s and all do different things for the same goal (fat loss). Now my question is how to go about this for the ultimate formula. Some say fasted cardio and maybe 2 out of 4 of these compounds when you start. Some may say split if all up throughout the day or right before your workout. Some may even adventure to say take them all at once and ride the wave!!! My goal is to pick everyone’s brain with these compounds. They all seem to work towards a common goal but differently. What, in your opinion, would be your way to approach such a stack like this for the best results that you can get. To make your point we can go a step further and talk about specific diets and training regiments. Would love to hear and understand everyone’s thoughts on this.
Timing is EVERYTHING
1 like • 13d
I've experimented with 5-Amino-1MQ myself, so I understand the curiosity about timing and how different metabolic pathways might complement one another. One thing I've learned is that half-life alone doesn't tell us whether stacking compounds improves results. With four compounds acting through different pathways, it would also be incredibly difficult to know which one was responsible for any changes you experienced.
1 like • 13d
@Logan Gregory I followed your jumble of thoughts perfectly! My brain often has 37 tabs open at any given time LOL I guess I assumed you hadn't tried any of these since I couldn't clearly pick up on it either way. And yes, that's essentially what I was getting at. If you're introducing several compounds, evaluating each one individually gives you a 𝗯𝗲𝘁𝘁𝗲𝗿 chance of identifying what's helping and what's causing problems. You are correct in that there's another wrinkle. Tolerating compound A and compound B separately doesn't necessarily mean they'll behave the same way together. Interactions can introduce effects that weren't apparent with either compound alone. So yes, I absolutely see your logic. My original point was simply that starting four 𝗻𝗲𝘄 different compounds together simultaneously makes it almost impossible to know what's responsible for what.
L-carnitine
Bought some l-carnitine from Swiss chems anyone know the dosages or a good pre workout dose?
1 like • 13d
I've spent a ridiculous amount of time researching L-carnitine and its different forms, and I actually use both oral and injectable L-carnitine myself. My interest is a little different, though. I've lived with ME/CFS for decades, so mitochondrial function, cellular energy, and neurological health are major areas of interest in my research. I don't use it as a pre-workout. I've explored L-carnitine, L-carnitine L-tartrate, acetyl-L-carnitine (ALCAR), and propionyl-L-carnitine. They're often lumped together, but research has investigated different applications, from muscle recovery and fatty acid metabolism to cognition and vascular health. One thing I've learned is that better absorption doesn't automatically translate into better fat loss or workout performance. Injectable L-carnitine bypasses the absorption limitations of oral carnitine, but getting more into the bloodstream doesn't necessarily mean more is getting into muscle tissue. Timing adds another wrinkle. Carnitine plays an important role in transporting fatty acids into mitochondria for energy production, but that may not mean taking it immediately before a workout produces an immediate performance benefit. There's quite a bit more to the carnitine story 🔬
1 like • 13d
@Kenney Stumpf YW 😊 Hope is helps.
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Robin R
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45 points to level up
@robin-riggio-7445
Independent researcher, focused on complex health & cognition. I question, look for patterns, focus on what actually works and share what helps.

Active 2h ago
Joined Sep 28, 2026
Tennessee
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