Why These Are Not the Same Thing There is growing confusion around kratom because some people claim that since mitragynine can convert into 7-hydroxymitragynine (7-OH) in the human liver, natural kratom is “basically the same” as commercial 7-OH products. That claim is scientifically incorrect. Here is the clear, factual difference. 1. Mitragynine and 7-OH Are Not Equivalent in the Body Natural kratom leaf contains mitragynine as its primary alkaloid. When consumed orally, a very small fraction of mitragynine is metabolized in the liver into 7-hydroxymitragynine. - This conversion is trace-level - It represents well under 1% of the mitragynine consumed - Most estimates place it around 0.01%–0.1% In practical terms, this means the body produces micrograms, not milligrams, of 7-OH. Commercial 7-OH products deliver milligram-level doses directly, bypassing the body’s natural metabolic limits. 2. The Liver Is a Limiting System, Not a Production Factory The human liver does not efficiently convert mitragynine into 7-OH. - 7-OH is a minor metabolic byproduct, not a primary outcome - Most mitragynine is converted into other metabolites, not 7-OH - First-pass metabolism naturally caps exposure This is a built-in biological safeguard. Commercial 7-OH products remove that safeguard entirely. 3. Potency Does Not Equal Exposure Yes, 7-OH is more potent per milligram than mitragynine. That fact is often misused. What matters is how much actually reaches the bloodstream. Natural kratom: - Slow oral absorption - Low peak concentrations - Mixed alkaloid profile - Trace endogenous 7-OH formation Commercial 7-OH products: - High potency - High concentration - Rapid spikes - No alkaloid balance - No metabolic ceiling These are fundamentally different pharmacological profiles. 4. A Simple Real-World Comparison A typical serving of plain-leaf kratom may contain 30–50 mg of mitragynine Endogenous 7-OH formation from that amount is measured in micrograms A single commercial 7-OH tablet may contain 10–20 mg of isolated 7-OH