Why These Are Not the Same Thing There is growing confusion around kratom because some people claim that since mitragynine can convert into 7-hydroxymitragynine (7-OH) in the human liver, natural kratom is “basically the same” as commercial 7-OH products. That claim is scientifically incorrect. Here is the clear, factual difference. 1. Mitragynine and 7-OH Are Not Equivalent in the Body Natural kratom leaf contains mitragynine as its primary alkaloid. When consumed orally, a very small fraction of mitragynine is metabolized in the liver into 7-hydroxymitragynine. - This conversion is trace-level - It represents well under 1% of the mitragynine consumed - Most estimates place it around 0.01%–0.1% In practical terms, this means the body produces micrograms, not milligrams, of 7-OH. Commercial 7-OH products deliver milligram-level doses directly, bypassing the body’s natural metabolic limits. 2. The Liver Is a Limiting System, Not a Production Factory The human liver does not efficiently convert mitragynine into 7-OH. - 7-OH is a minor metabolic byproduct, not a primary outcome - Most mitragynine is converted into other metabolites, not 7-OH - First-pass metabolism naturally caps exposure This is a built-in biological safeguard. Commercial 7-OH products remove that safeguard entirely. 3. Potency Does Not Equal Exposure Yes, 7-OH is more potent per milligram than mitragynine. That fact is often misused. What matters is how much actually reaches the bloodstream. Natural kratom: - Slow oral absorption - Low peak concentrations - Mixed alkaloid profile - Trace endogenous 7-OH formation Commercial 7-OH products: - High potency - High concentration - Rapid spikes - No alkaloid balance - No metabolic ceiling These are fundamentally different pharmacological profiles. 4. A Simple Real-World Comparison A typical serving of plain-leaf kratom may contain 30–50 mg of mitragynine Endogenous 7-OH formation from that amount is measured in micrograms A single commercial 7-OH tablet may contain 10–20 mg of isolated 7-OH

Quick recap The meeting focused on discussing a fire incident at Venus's home and the subsequent support efforts. Christopher shared that Venus's basement had caught fire, though the damage appeared contained, and she had found one of her cats, Onyx. The group discussed the importance of contacting the Red Cross for assistance with temporary housing and the potential need to disconnect electrical service due to wiring concerns. The conversation then shifted to broader topics about kratom regulation, including recent bans in Louisiana and challenges with synthetic versions like 7-OH. Participants shared personal experiences with kratom usage, including its effects on pain management, mental health, and focus, while emphasizing the need for proper education about safe usage. The discussion also touched on upcoming industry events and the changing landscape of kratom vendors in trade shows. Summary Fire Incident Support Discussion Christopher discussed a fire at Venus's house, which was contained in the basement. Robin advised that Venus should contact the Red Cross for assistance with temporary housing and other support, as the fire department may pull the electrical meter if there's damage to wiring. Christopher agreed to inform Venus about the Red Cross services and mentioned that he had prepared an emergency kit for her. Kratom Legal Status Discussion The group discussed various plant medicines, particularly focusing on kratom and its legal status. Leon shared that Louisiana had banned kratom and cannabis-derived products, though edibles remain legal. The conversation touched on the differences between kratom and kava, with Christopher noting that kava produces a calming effect rather than the pain and energy relief provided by kratom. The discussion concluded with a brief mention of previous efforts to classify kratom as a safe substance for religious use in 2017. Medicinal Plants Legal Discussion Christopher and Robin discussed their experiences with medicinal plants, particularly Kratom and cannabis. Christopher shared how Kratom helps him manage pain and stay focused during the day, while Robin mentioned that cannabis benefits him for medical conditions but isn't functional for daily use due to its psychoactive effects. They expressed frustration about restrictive laws regarding growing medicinal plants at home, with Christopher noting that New Jersey, despite allowing medical marijuana use, prohibits patients from growing their own plants, while other states like Michigan and Louisiana have been considering or implementing bans on Kratom cultivation and sales.

Quick recap The meeting focused on the ongoing challenges and advocacy efforts surrounding kratom, including recent legislative hearings and the division within the community over 7-0H products. Participants discussed the need for education and regulation rather than prohibition, sharing personal experiences and concerns about the current state of kratom advocacy. They highlighted the importance of collaboration between vendors, consumers, and organizations to address misinformation and promote responsible use. The conversation also touched on the business aspects of selling kratom, including the challenges vendors face and the role of co-packers in ensuring product quality. Throughout the discussion, participants expressed frustration with the lack of progress in achieving a balanced approach to kratom regulation and the ongoing conflicts within the community. Summary Kratom and Legal Updates Christopher and Robin discussed their busy schedules, including recent hearings and surgeries. They also talked about Christopher's kratom plants and plans to repot them. The conversation then shifted to recent hearings in Tennessee and Georgia, with Robin expressing frustration at the lack of progress in some states. Christopher suggested the idea of implementing a kiosk system in shops selling kratom to provide information to customers. Website Challenges and Testimony Planning Robin and Christopher discussed challenges with their website and communication efforts, including outdated information and difficulties with PDF links. They expressed frustration over people dismissing scientific facts and research on kratom, with Christopher mentioning his expanded testimony to address this issue. Robin suggested making their success stories as compelling as the tragic stories on the other side, while Christopher debated whether to include certain points in his testimony. Kratom Regulation Advocacy Discussion Christopher and Robin discussed the challenges of advocating for kratom regulation while managing personal and professional responsibilities. Christopher shared his extensive documentation on kratom's safety and regulatory issues, which he sends to various states and municipalities. They agreed on the need for a balanced approach to kratom regulation, emphasizing education, age restrictions, and responsible distribution rather than prohibition. Christopher also shared a personal anecdote about a kratom user who switched from high-concentration products to lower doses, highlighting the importance of regulated, lower-strength kratom products in preventing abuse.

The Tennessee hearing scheduled this week has been rescheduled for next week on 3/16 & 3/18 Thank you to everyone who attended and we know it is a sacrifice but need an even bigger turnout next week. We must keep the pressure on lawmakers. ACTION:Visit protectkratom.org/tenn Arizona – Senators Need to Hear From You Arizona Senators are currently considering HB 2415, and it is critical they hear from kratom consumers about the importance of protecting safe access. need to hear from kratom consumers about the importance of responsible regulation and consumer protection. ACTION:Contact Arizona lawmakers here:Go to protectkratom.org/arizona Virginia – Ask the Governor for Amendments Virginia passed a flawed kratom bill that could harm responsible consumers and vendors. Advocates should ask the Governor to push for amendments to improve the bill. ACTION:Message the Governorprotectkratom.org/virginia

A live, come-as-you-are conversation about natural kratom and herbal wellness. Join us for Christopher’s Weekly Tea Talks every Thursday at 7 PM EST, where I host a live Zoom session where people can learn about natural kratom, ask questions, connect with others, and hear exactly what is happening in the real world not just in politics or the media, but in the everyday lives of consumers, small businesses, and the farmers who grow this plant. The world of wellness is evolving, and with it comes the necessity for open dialogues about natural remedies. In our discussions, we emphasize the importance of understanding both the benefits and risks associated with herbal supplements, especially kratom. Many individuals are seeking alternatives to traditional pharmaceuticals, and kratom has emerged as a popular choice. It’s crucial to share real-life experiences that highlight both the positive outcomes and the challenges faced by users. During our sessions, we focus on practical advice and real stories from people who have integrated kratom into their lives. This personal touch makes our discussions relatable and informative. We often feature guest speakers who share their journeys with herbal medicine, which adds a diverse perspective to our conversations. This format encourages a deeper exploration of topics that are often overlooked. For instance, we discuss recent research findings on kratom and its potential therapeutic benefits. By examining studies, we equip our community with factual information to make informed decisions. Talk Beyond Just The Headlines Natural kratom has helped countless people reclaim quality of life, yet most of what the public hears comes from headlines, not real humans with real experiences. Christopher’s Weekly Tea Talks is where that changes. Moreover, we aim to demystify kratom by addressing common myths and misconceptions. This awareness is essential in navigating the discourse surrounding kratom, especially in light of regulatory challenges.