I'd suggest following Taylor Reid Wiliams on Youtube who addresses HRT and peptides for women. https://www.youtube.com/@taylorwilliamscoaching

@Martin Sherman Haven't tried MA-5 yet, but researching it. Thanks for info!

@Martin Sherman Looked at some of Doris Loh's info and how it fits into some of the clinical trials at higher dose Melatonin, and it seems like her work relies heavily on laboratory physics models rather than human patient outcomes. Clinical trials typically evaluate melatonin for sleep and circadian rhythms, but recent studies also highlight its metabolic impacts, while the independent theory of Doris Loh views melatonin as a biophysical regulator of cellular clumping. What Clinical Trials Show About 5mg Melatonin Most clinical trials investigate melatonin for jet lag, shift work, and insomnia. However, modern trials are also exploring how daily dosing impacts the rest of the body: - Metabolic and Glucose Impacts: A 2026 randomized, double-blind clinical trial published in Diabetes Care evaluated a daily 5mg oral melatonin dose. The study discovered that taking melatonin can worsen glucose tolerance and blunt insulin responses. This effect was especially severe in individuals carrying a common genetic variant (MTNR1B), which is linked to an increased risk of type 2 diabetes. - The "Bulk Dosing" Standard: Traditional clinical trials focus on systemic absorption and how a dose impacts sleep or specific organs as a whole. The Biophysical Theory of Doris Loh looks at melatonin through the lens of physics and chemistry rather than traditional biology. Her core hypothesis focuses on Liquid-Liquid Phase Separation (LLPS) and how melatonin functions at a cellular level: - The Mechanism (Cellular Clumping): Proteins and RNA inside cells naturally separate into droplets, similar to oil in water, forming "membraneless organelles". When this process malfunctions (aberrant phase separation), proteins dry out and form hard, toxic clumps. According to Loh, this driving force is behind diseases like dementia (amyloid-β plaques), cataracts, and cancer. - Melatonin as a "Biophysical Buffer": Loh argues that melatonin's primary job is not just to make us sleepy, but to act alongside ATP (cellular energy) to keep cell fluids moving. Her papers state that melatonin reduces cellular viscosity, traps necessary water molecules around proteins, and dissolves toxic aggregates before they can cause damage. - Viruses and Cancer: She proposes that viruses like SARS-CoV-2 hijack phase separation to build "viral factories" inside cells. In oncology, she asserts that melatonin switches roles to act as a pro-oxidant that deliberately breaks down the protective fluid sanctuaries of cancer cells. - Dosing Implications: Because of this broad cellular role, Loh's theories often support using precisely calibrated or higher doses of exogenous melatonin to combat acute infections, cancer, or neurodegeneration, deviating from standard micro-dose sleep guidelines.

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