Alright community, it's time to share my experience with retatrutide in a muscle growth/bulking context. Let me break down the science AND my real-world results. Remember all of this info is for research purposes only, not medical advice, and do not copy. Understanding Retatrutide: The Triple Threat Retatrutide hits THREE different receptors. Here's what each one does: 🎯 GLP-1 Receptor: - Slows how fast your stomach empties - Reduces appetite through brain signaling - Helps your pancreas release insulin when you eat - Lowers glucagon (which normally raises blood sugar) 🎯 GIP Receptor: - Boosts insulin even more than GLP-1 - Improves how your body handles fat and nutrients - Reduces food intake through different pathways - Makes fat cells more insulin sensitive 🎯 Glucagon Receptor (THE KEY DIFFERENCE): - Increases your metabolic rate - Burns stored fat for energy - Reduces fat buildup in your liver - Helps preserve muscle during weight changes Why Reta Feels "Weaker" Than Tirzepatide Here's the thing: retatrutide's GLP-1 activation is intentionally weaker than tirz or sema. Why? Because glucagon normally increases appetite and blood sugar. So you need some GLP-1 to balance it out, but not so much that you kill your appetite completely. This is actually PERFECT for bulking. The gastric emptying is there, but way less pronounced. I've never gotten the same food noise reduction on reta compared to tirz. And that's exactly what you want when you're trying to EAT to grow. The "Eat More, Gain Less Fat" Phenomenon This is where it gets crazy. Here's what's actually happening: 1️⃣ Your Metabolism Runs Hotter Glucagon activation increases your metabolic rate by 5-10%. You're literally burning more calories doing nothing. 2️⃣ Your Body Burns Fat Preferentially Even when you're eating MORE, the glucagon component shifts your body to burn fat for fuel instead of storing it. You're in a surplus, but calories are being oxidized, not stored. 3️⃣ Better Nutrient Partitioning

After trying DSIP with zero results, I found something that actually worked. Not a sleep "drug." Not another melatonin supplement. A peptide that works through an entirely different mechanism—one that's been studied for 35+ years (mostly in Russia) with some pretty wild implications beyond just sleep. The best part? The sleep improvements feel natural. No grogginess. No dependency. Just easier wind-down and better quality rest. What makes it different: It doesn't just knock you out like a sedative. It works by regulating your pineal gland and supporting your body's natural melatonin production. But that's just the beginning of what it does... The deeper mechanism involves something called telomeres (your cellular "aging clock") and an enzyme most of your cells don't produce anymore. I broke down the full science, mechanisms, research, and my lab rat's 15-day protocol in my latest deep dive. Read the full breakdown here: https://open.substack.com/pub/derekpruski/p/understanding-epithalon-the-longevity?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Including: ✅ How it actually works (explained simply) ✅ Why telomeres matter for sleep AND longevity ✅ The research behind it ✅ Real-world 15-day protocol results ✅ Dosing and cycling protocols Worth a read if you're struggling with sleep or just curious about the intersection of peptides, longevity science, and cellular health. Drop a comment if you've tried this one—curious to hear your experiences. 👇

Good evening, everyone, I hope you are all well. Sitting around being bummed the Lions lost, but enjoying my time with amazing family and awesome food! I'm sitting back trying not to fall into a food coma and am reflecting on all I have to be grateful for this year. I got a new meniscus that healed very well and quick. I got sober thanks tona great recovery center and AA. Mostly though is all the great people I have met in these communities that have embraced and encouraged all the new people including myself! One big group of like minded people. Just like in the AA Big Book, my favorite sentence in all the book is, "We are people who normally would not mix". That also describes most of us in these communities. We are truly people that would not mix (meaning without this platform we wouldn't know each other), we come from all over the world, different back grounds, different races, religions, ages, places in our fitness journeys, even different goals. But here we are, like minded people that just want to be the healthiest versions of ourselves. Happy Thanksgiving everyone, we are all now, one big peptide family!! 🫶🖤🦃💪

To everyone in this community and everyone who has used https://peptideprice.store – I can't say it enough: you truly have changed my life. When I created the Price Tool, my goal was simple: make it easier for people to get into the research space and not waste thousands of dollars each month on the same product. I thought maybe 1-2 people might find some value in it, but I could never have imagined growing it to this size. I've been able to research and make posts about what interests me most about peptides. I will never stop helping because the stories I hear from you guys – your transformations, the benefits you're seeing – it's amazing and shows me how needed this community truly is. Once again, thank you for all the support through all the bans, all the takedowns, everything. I say it a lot, but this is my second family. Enjoy your Thanksgiving with some good food and quality time with friends and family. 🦃 – Derek

The first AMC Essentials giveaway has officially wrapped and we have our winners! Congratulations to: 🏆 Jillian Wamhoff - $200 store credit 🏆 Kristen Melby - $200 store credit 🏆 Eduardo Echeverria - $200 store credit Winners, check your email for details from AMC soon! Big thank you to AMC Essentials for being so generous with the community and for being a trusted partner on PeptidePrice. This is what happens when vendors actually care about the research community 💪 Congrats again to our winners! 🎊 peptideprice.store, we still have many more giveaways to announce!