@Adithya Ravichandran 29yo. In theory: Hypotalen, Endocron, and Testovive to heal the core players of the HPTA. Nice to haves: Adrenact, Thymusol, Suprefort (pancreas), and Liverra. Russian research showed modest contributions from the adrenal, thymus, and pancreatic bioregulators. Intuitively I thought the liver bioreg might have helped lower my SHBG, but it didn’t happen that way. Also, a healthy liver may be more effective at producing growth factors like IGF-1 and it’s probably not a bad idea for anyone running SARMs to run a liver bioregulator to help protect the liver, but there are lots of ways to do that. I may be adding in boron in the future to see how it affects my SHBG.

@Adithya Ravichandran Yes, that would be the core if you want to go the way of bioregulators. However, some nuance that may allow you to go cheaper. If you know your problem is an upstairs problem (Secondary Hypogonadism, where the hypothalamus/pituitary are not getting enough LH to the testes (but they are still producing some LH)), Enclomiphene may be the cheaper option short term. If your problem is downstairs (Primary Hypogonadism, where the testes aren’t responding to high LH levels) Testovive alone may get you there. If you want to be even more natty than Enclomiphene, hitting all three of the HPTA bioregulators is the way to go. The advantage of the bioregulators is that their affects will be much longer lasting than Enclomiphene, since they are modifying epigenetic expression (which can persist for months) vs blocking receptors for Estradiol in the Hypothalamus like Enclomiphene which has a short half life and is out of your system quickly. Not my referral code (I don’t have one), just one that I’ve found for 10% off of Vita-Stream products: changeage10

I've been taking 3 of those/day for months, I've dropped down to 2 now after getting my latest labs. Calcium is at the upper end of the range.

@Bence M Yep, same exact Dr. Berg supplement.

Stumbled upon this community through the Natty Plus Protocol YT channel and followed the rabbit hole here. I'm a T1D looking for remission/getting off of insulin (been getting progressively more advanced in what I'm trying over the past few years). I found the Natty Plus Protocol channel while going down the testosterone optimization rabbit hole. T1Ds have low T/IGF-1 levels years prior to diagnosis, so I figure remedying that is an important step. To start out I'm running some oral bioregulators (peptides) to try to give my HPTA a boost/rejuvenation. More Natty with zero risk if it works and changes things at the epigenetic level (effective age reversal in my mind). 30mg a day of each of the following for one month to start out followed by a retest of levels is the plan before reevaluating next steps (I have limited labs I had done just before starting which I'll share further on in this post): - Hypotalen (hypothalamus bioregulator) - Endocron (pituitary bioregulator) - Liverra (liver bioreg) - Testovive (testicular bioreg) - Adrenact (adrenal bioreg) I've also added in a B-Complex, DHEA, some caffeine, and dumbell lunges to help my T levels. I've also upped my carbs a bit and protein intake to hopefully bring my SHBG down. Initial labs: - Total T: 583 ng/dL - Free T: Quest calc’d 43.7 pg/mL, ISSAM calc’d 7.58 ng/dL - SHBG: 64 nmol/L - Bioavailable T: Quest calc’d 97.4 ng/dL, ISSAM calc’d 201 ng/dL - Albumin: 4.9 g/dL In summary, my Total T is too low, SHBG is too high which makes my Free T/Bioavailable T too low as a result. I’m hoping to bring my levels closer to: - Total T: 880-1200 ng/dL - Free T: ISSAM calc’d 20-40 ng/dL - SHBG: 25-35 nmol/L - Bioavailable T: ISSAM calc’d 512-752 ng/dL Next labs I'll probably add LH/FSH and some measure of iron (I haven't decided which yet). If I'm in a decent range I'll probably add in some Enclomiphene for a bit prior to a sarm cycle (possibly some Test Cyp also depending on what i learn here) to boost my muscle mass for improved insulin sensitivity. I'm eying 140 Ibs at 9-11% body fat as an initial target (5'8.5"). Nothing too crazy. I'll reevaluate from there.