Hey all, I’m putting together a plan for an IGF-1 LR3 run and wanted to get some experienced opinions, specifically around cycle length. I know the standard protocol is 4-6 weeks due to receptor desensitization . However, my situation is a bit specific, and I’m trying to figure out if the standard advice applies the same way to me. My Situation: · I have 2mg total of IGF-1 LR3 to work with. · My plan is an 8-week cycle, tapering the dose to make the supply last (e.g., 30/35/40/40/40/40/30/30 mcg/day or similar). · I will not run IGF-1 LR3 again for a very long time (at least a year or two) after this. Receptor resensitization for a future cycle is not a concern for me. · About a month after finishing the IGF-1 LR3, I plan to hop back on Retatrutide. I’m also on 25 mg Mk677 right before sleepjng My Understanding (and Questions): 1. Receptor Desensitization: My primary research tells me this is the main reason for short cycles . Since I'm treating this as a one-and-done blast, is receptor sensitivity still a critical factor? Or does the risk of diminished returns in the final weeks outweigh the benefit of running it longer? 2. Are there other risks with a longer cycle? Besides getting used to it, what other potential downsides should I be aware of with an 8-week run? · Hypoglycemia & Insulin Resistance: I know LR3 has a ~20-30 hour half-life and impacts glucose uptake . Does the risk of developing insulin resistance increase significantly after 6 weeks? · Mitogenic/Cellular Growth Concerns: I've read about the theoretical risks of IGF-1 promoting cell proliferation and its link to cancer pathways . Is an extra 2-4 weeks of exposure in a single cycle a meaningful increase in this theoretical long-term risk? · Systemic Stress: Will running it for 8 weeks put more strain on things like appetite, digestion, or cause other systemic sides that typically ramp up after a month? I get that more isn't always better, but I’m trying to balance making the most of the supply I have with not being stupid about it. If the only real downside of an 8-week cycle is that I might get slightly diminished returns in week 7-8, I can live with that. But if I'm significantly increasing my risk of insulin sensitivity issues or other long-term problems, then I'll stick to the 4-week protocol.