When the clinic I used to work at started their semaglutide centered weight loss, they gave us the option to try it. I did couple of months titrating according to their protocol. I do not have food "noise". I have fat loss resistance (long genetics story). I used for two months or so and decided GLP-1 was not for me. I lost muscle because i would completely forget to eat and my work out suffered. Energy suffered Five year later I became intrigued with Reta because of glucagon (mainly). So I have been titrating for 6 weeks. I am on a 4 gr/wk. The info I have is that 6mg is the optimal for my goals and size. Experience has been different in the sense that I feel the glucagon working. I am not tired. Still have to pay attention to eating enough, but I am able to pick protein and complex carbs easily. once a week I need a simple carb. I do not weigh myself (another story), rather go by body comp and mirror. So my expectation is to see results in the longer term. However, I had a yearly physical this week and had a preop consult in June. There was 15 lbs loss. I am not in the ideal state as I am recovering from knee replacement which is affecting my quality of sleep, but, I am noticing steady energy through out the day even with less than 7 net hours of sleep. I have experienced no side effects (nasuea, constipation, etc) This week I added 1mg of tesamorelin to attack visceral fat and started using a CGM. The CGM data is so different from my "normal" (in a good way) that I don't trust it. Very smooth curve. Curious if I could bring the average and early morning close to 80. So far positive experience with Reta