https://www.facebook.com/share/p/1CU1QfHe5u/ Johns Hopkins’ New Mebendazole Patent and Its Significance for Cancer Therapeutics A recent public news article has highlighted a development that deserves serious attention within oncology and drug-repurposing research: Johns Hopkins scientists have patented a new crystalline form of mebendazole—referred to as polymorph C—designed to enhance its anti-cancer properties. Background: Why Mebendazole Matters Mebendazole is a benzimidazole-class anthelmintic with a well-characterised safety profile accumulated over ~40 years of clinical use. Beyond its antiparasitic activity, numerous preclinical studies have demonstrated: Microtubule inhibition in cancer cells Disruption of glucose metabolism in malignant tissues Interference with multiple signalling pathways (Hh, Wnt/β-catenin, Bcl-2) Selective cytotoxicity to tumour cells at concentrations tolerated by normal cells Despite these properties, clinical adoption has been limited largely because the original molecule is off-patent, making large-scale commercial trials financially unviable. What Johns Hopkins Has Patented The new patent centers on: Polymorph C — a redesigned crystalline form This form appears to demonstrate: Improved oral absorption Higher plasma concentrations Prolonged systemic exposure Greater potency in killing cancer cells in vitro compared with existing polymorphs This is scientifically notable, because mebendazole traditionally suffers from: Poor gastrointestinal absorption High inter-individual variability Low bioavailability unless taken with high-fat meals A more bioavailable crystalline form directly addresses these limitations. Synergy Through Transporter Inhibition The Johns Hopkins team also referenced co-administration with elacridar, a potent inhibitor of: P-glycoprotein (P-gp) Breast Cancer Resistance Protein (BCRP) These efflux pumps are responsible for removing chemotherapeutic agents from cancer cells.

Hi all, This was something I only recently became aware of so though i should share it. Key Findings from Research :https://pmc.ncbi.nlm.nih.gov/articles/PMC3262853/ Animal Study Evidence: A 2011 study in mice found that pretreatment with fenbendazole (at doses equivalent to 8–12 mg/kg/day for 7 days) significantly worsened acetaminophen-induced liver damage. Specifically:Acetaminophen alone caused centrilobular hepatic necrosis and elevated liver enzymes (ALT/AST) within 12 hours.When combined with fenbendazole, the damage was more extensive, with greater necrosis, higher enzyme levels, and 63% mortality within 24 hours.Fenbendazole alone did not cause liver issues.The mechanism appears to involve prolonged depletion of glutathione (GSH), a key antioxidant that detoxifies acetaminophen's toxic metabolite (NAPQI). Fenbendazole delayed GSH recovery without altering acetaminophen's metabolism or major cytochrome P450 enzymes (except a minor suppression of CYP1A2).This interaction was investigated because fenbendazole is commonly used in lab rodents, and it highlights a potential drug-drug effect in hepatotoxicity models. Human Relevance: There are no published clinical trials or case reports confirming this interaction in humans. Fenbendazole is not FDA-approved for human use (it's a veterinary dewormer), so data is limited to off-label contexts like experimental cancer protocols. Both drugs are metabolized in the liver via the cytochrome P450 system, which could theoretically lead to similar risks, such as altered drug clearance or compounded stress on liver function. Sites promoting fenbendazole use (e.g., for alternative therapies) note this as a speculative concern and recommend monitoring liver enzymes (ALT/AST) if combining them, along with liver-supportive supplements like milk thistle.

Presently, the subscapular pain due to the cancer in my spine and ribs has been particularly bad, with sharp, stabbing pain. The pain in my left hip has moderated greatly. then moved to my right hip, and has moderated a lot the past week, so the left subscapilar pain is still the focal point of pain. I got back on Celebrex this week, since I can now use Tylenol, in moderation, which is a Cox 2 inhibitor, one type of pain that Tylenol is good for dealing with. It was able to help me reduce my need for morphine, but after 3 days of going cold turkey to get off morphine, I have found the kind of pain morphine is good for removing, has still been needed as the pain level reaches 9 and 10 at times. Since my histotripsy I received in Oregon, 10/23/25, about 1/3 of my cancer was ablated from the 2 larges masses, which allowed me to get back on Tylenol products when needed. I have been acutely aware that one cannot live with level 9 and 10 level pain, no matter how hard one tries. I used ice packs, gabapentin, and alternated with hot backs, and did contrast therapy, and whirlpool, and am waiting to receive a pulsed ultrasound from China, and don't know when it will arrive, as it's being held up with tariffs, though taxes, and duties were prepaid. When my friend Dr. Howard returns from Spain, he told me to come to his house and we will try various modalities, as he doesn't want to see me on pain meds anymore than I have to. The cryoablation is scheduled for the 21st of this month, which should remove 90% of my pain generation, and pain meds that go with it. How is everyone else dealing with their cancer pain?

I returned home after a 10-day trip, first for liver ablation using Histotripsy, at Good Shepherd Hospital in Hermiston, OR, by Dr. Kevin Burns, then to Mission Hospital for PEF (Pulsed Electric Fields) in Mission Viejo, CA, again performed by Dr. Kevin Burns. PET/CT scans will be performed at 3, 6, and 12-month intervals, with complete resolution expected for lung cancer nodule (PEF Protocol), and since I go back in December for further liver ablations, the PET/CT scans will show inflammation and a gradual decrease in SUV (Standardized Uptake Value) at each 3-month re-scan interval. Dr. Burns was trained at MD Anderson by Dr. Rahul Sheth, with whom I have a conference call on Monday, and whom will perform other ablations for my bone and joint cancers. Treating cancer this way, through ablations, will spare normal tissue from the necrotizing effects using radiation and other harmful substances, and liquid biopsies will be done at appropriate intervals to assess the cancer cell counts to insure we are keeping up with cancer mutations. Diet will be ketogenic, going by GKI readings, and will be viewed as Mediterranean, using a rotation of fish with some inclusion of beef and low-carb greens/vegetables. My weight has been between 65-67 Kg, the lowest I've been since college days, mostly due to the cachexia of cancer. Exercise is almost completely aerobic, as weight training is ruled out until bone and joint cancer is eliminated, due to high risk of fracture. Whenever that risk is eliminated, my weight will get in a healthier range between 70-75 Kg, as I rely more on body composition than scale weight, muscle being more protective of skeletal and organ systems. I took my second round of subQ Anktiva this week, taking it every 21 days, and keeping track of ALC, and NK cell counts, along with additional immunological tests, recommended by Dr. Gregory Howard, from the HRF (Hippocrates Research Foundation).

Pre--Histotripsy Evaluation: 2 masses, 1 smaller than the other, with the smaller mass described below: Within the central right hepatic lobe, there is the suggestion of a subtle mass measuring approximately 5.0 x 4.5 x 3.cm that is 5.2 cm from the center of the mass to the muscle and 6.5 cm from the center of the mass to the skin. The larger mass is as described below: Within the left and right hepatic lobes, there is the suggestion of an additional subtle mass measuring approximately 12.4 x 8.2 x 12.3 cm that is 6.5 cm from the center of the mass to the muscle and 7.7 cm from the center of the mass to the skin. The procedure was to aim the acoustic pathway (done through a water bath suspended over my abdomen, as the acoustic waves are accomplished through the medium of water, air not being a viable medium). The larger mass was done using a 4.0 cm cavity, with treatment time of 23 minutes, 10 seconds at an avg. voltage of 63.5%. The smaller mass had a cavity size of 3.0 cm, with treatment time of 12:01 at an avg. voltage of 56.8% I had an abdominal MRI w/ and w/o contrast today, but don't have the radiology report yet. The goal is to treat a small portion of the cancer with the hope of creating an abscopal effect, whereby the tumor antigens given off during the procedure can be used to identify my particular liver cancer and my own immune system can help eradicate my cancer elsewhere in my body. I fly to Dr. Burns office in Mission Viejo for treatment with PEF (Pulsed Electric Fields) for my lung cancer and hip cancer, and eventually other cancers in my spine and skeletal system. Since Dr. Burns trained at MDA, he knows the doctor that did the RF ablation to my thoracic spine last year, and where appropriate, can treat me again. I will also hear from Dr. Jason Williams next week, as they studied my scans and medical records at their tumor board today. My research has led me to (1) build up my collapsed immune system with Anktiva, consisting of a subQ injection every 21 days, (2) going directly to the cancer using various ablation techniques, with the specific goal of encouraging the abscopal effect(s).