Let's cover another issue that pops up with MOTS-C that I don't see any other creators talk about. A lot of people ask why I've landed at a research amount of 0.5mg - 1mg 5x per week instead of the higher protocols. Let's break it down in detail, drop a 🔥 if you want more in-depth content on topics not frequently discussed like this. For research purposes only. This is not medical advice. If you've been curious about MOTS-c for metabolic benefits, energy, or exercise performance — there's something worth understanding before you jump in with aggressive dosing. The Histamine Connection MOTS-c can trigger histamine release in some people. This isn't necessarily a sign something is "wrong" — it's actually a known downstream effect of how MOTS-c interacts with cellular signaling. But when you hit your system with a large bolus dose (say, 5mg three times per week), you're essentially flooding the pathway all at once. For some folks, this means: - Flushing, redness, or warmth at injection site or systemically - Itching or hives - Headaches - Feeling "off" or overstimulated - Feeling more tired in general - In more sensitive individuals, more pronounced allergic-type reactions Sometimes your system can go into overdrive and paradoxically make you feel more tired — the opposite of what you're going for. When the body is busy managing an acute histamine response, you're not getting the clean energy and metabolic benefits you signed up for. The Problem with Big Bolus Doses The 5mg 3x/week protocol gets thrown around a lot, but here's the issue — MOTS-c is a mitochondrial-derived peptide that works on AMPK activation and metabolic regulation. These are systems that respond well to consistent signaling, not necessarily massive spikes. When you slam 5mg at once: 1. You get a rapid peak that can overwhelm histamine clearance pathways 2. The body's response becomes more about managing the acute "event" than the gradual metabolic benefits 3. You may actually be reducing the usable window of the peptide's action

What's one would be better to pair with Reta?

Anyone using these two together, if so what's your protocol? I'm thinking of adding tirz to my stuff.

Just got labs and my RBC is high. HCT is high and my Hgb is high. 😒

Anyone have trouble with absorption rate? For me I have trouble with things having any effect, like caffeine does nothing for me.