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Did anyone else feel fatigue on Mot-c I’m Going on week 4 tomorrow running every other day but the fatigue is not fading stacking with GLOW daily and Reta 2 days week. Curious if anyone else had the fatigue and how long ❤️🙏

General Rule (Across Most GLP-1s) For medications like semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound): Increase dose every 4 weeks (minimum) This is considered the standard titration schedule. Why 4 Weeks? Allows your body to adapt to appetite suppression + slowed gastric emptying Reduces risk of: o nausea o fatigue o reflux Helps stabilize blood levels due to long half-life Typical Titration Examples Semaglutide Week 1–4 → 0.25 mg Week 5–8 → 0.5 mg Week 9–12 → 1.0 mg Then increase as needed Tirzepatide Week 1–4 → 2.5 mg Week 5–8 → 5 mg Week 9–12 → 7.5 mg Continue upward if needed When NOT to Increase Hold your current dose longer if: You’re still losing weight effectively Appetite is already very suppressed You have side effects: o nausea o fatigue (you mentioned leg fatigue) o difficulty eating enough In these cases, staying at the same dose longer is actually smarter (and often gives better long-term results). Advanced / Biohacker Approach With microdosing strategies Many people don’t follow strict 4-week jumps Instead: o Increase very gradually (every 2–4+ weeks) o Or don’t increase at all if results are strong o Focus on: appetite control energy body composition (not just scale) This often leads to: fewer side effects better muscle retention more sustainable fat loss Bottom Line ✔ Standard: increase every 4 weeks ✔ Smarter: increase only when needed ✔ Advanced: stay low as long as it’s working Retatrutide is a little different from traditional GLP-1s—and this is where things get interesting What makes retatrutide different? It targets GLP-1 + GIP + glucagon receptors Much stronger metabolic effect Longer activity → more aggressive appetite + fat loss response Because of this, titration needs to be even slower and more controlled than semaglutide or tirzepatide. Clinical Trial–Style Recommendation In studies, retatrutide was increased: Every 4 weeks (or longer) Example titration used in trials: Week 1–4 → 1 mg

Who has seen the commercials for the new GLP-1 pills? Every time I see these commercials.....my eyes roll....straight out of my head! 👀 Here is the SCIENTIFIC REASONING behind why GLP-1 pills are one of the biggest GIMMICKS right now: GLP-1 “pills” sound convenient—but the reason most don’t work well (or at all) comes down to basic biochemistry and human physiology. Here’s the science broken down clearly: 1. GLP-1 is a fragile peptide (not a typical drug) GLP-1 drugs (like semaglutide, tirzepatide, or liraglutide) are peptides, meaning they’re made of amino acid chains—basically like tiny proteins. Problem:Your digestive system is designed to break proteins apart. - Stomach acid (pH ~1–2) denatures peptides - Enzymes like pepsin, trypsin, and proteases chop them up Result:Before a GLP-1 peptide can reach your bloodstream, it gets destroyed in your gut 2. Poor absorption through the intestinal wall Even if some peptide survives digestion: - Peptides are large and water-soluble - The intestinal lining prefers small, fat-soluble molecules This creates a major barrier: - GLP-1 molecules can’t easily pass into the bloodstream Result:Very little (if any) active drug gets absorbed 3. Rapid breakdown by enzymes (DPP-4) Your stomach DESTROYS peptides GLP-1 drugs like semaglutide, tirzepatide and liraglutide are peptides (chains of amino acids). Your digestive system is literally designed to break these down. - Stomach acid = extremely harsh (pH 1–2) - Enzymes = protein-cutting machines Even if GLP-1 makes it into circulation: - It’s rapidly broken down by an enzyme called Dipeptidyl peptidase-4 (DPP-4) Natural GLP-1 has a half-life of:~1–2 minutes Result:It disappears almost immediately unless chemically modified 4. Why injections work (and pills struggle) Injectable GLP-1 drugs are engineered to bypass all of this: - Avoid the digestive tract entirely - Modified to resist DPP-4 breakdown - Designed to resist breakdown - Stay active for days instead of minutes - Designed for slow release (long half-life)

https://people.com/mental-health-benefits-may-be-linked-to-glp-1-weight-loss-drugs-in-new-study-11932901