I am doing 50 units of carved fasted first thing in the morning and I’m having great clean energy and focus during the day but come 8-9 pm and I am crashing. I’m used to having late nights. Do I need to lower the dose or start maybe titrating up?

I've been seeing arguments online about how microdosing retatrutide or splitting up your dosing into multiple doses throughout the week is less effective and could possibly be more harmful than taking a single weekly dose, particularly to the pancreas. Thoughts and explanations?

If you are on the fence about getting some peptides for the Halloween sale Reta One Labs is having don’t be. Order my peptides on Tuesday for a great price, and it arrived today on Thursday. Come wrapped and in this pretty blue satchel. The entire experience was great for me.

Hey everyone! So split dosing is blowing up right now in the research community - especially with Sema, Reta, and Tirz. After diving deep into the literature (video coming soon), I think I understand why researchers are seeing better results when they divide their weekly doses into multiple administrations. Let me break this down in a way that actually makes sense... The Problem With Weekly Administration You know that feeling when effects start wearing off around day 5 or 6? There's a reason for that. When you dose once a week, you get this huge spike of the compound on day 1, then it slowly drops off. By the end of the week, you're running on fumes. It's like filling your gas tank once a week vs topping it off every few days - one gives you feast or famine, the other keeps you steady. Research actually backs this up. Scientists found that splitting your dose can reduce those massive peaks by almost 40% while keeping your levels more stable. And get this - even when people switched to every-other-week dosing in studies, they still kept 75% of their weight loss. That tells us something interesting is happening here. My Theory: It's All About Giving Your Receptors a Break 🧠 Here's where I think most people are missing the bigger picture... Everyone talks about keeping stable drug levels, but I think there's something way more important happening with your receptors. Think of GLP-1 receptors like doorways on your cells. When you blast them with medication 24/7, they basically get exhausted and start hiding inside the cell. Scientists call this "internalization" and it happens FAST - like within 2-3 minutes of exposure. Now here's the kicker - when you split your dose, you're not hitting those receptors as hard. You're giving them little breaks to come back to the surface and recover. It's like interval training vs running a marathon - which one would exhaust you less? The "Natural GLP-1" Factor Nobody Talks About This is what really got me thinking... Your gut naturally makes GLP-1 when you eat. But if your receptors are completely overwhelmed with medication all the time, can your body's own signals even get through? It's like trying to hear someone whisper while you're at a rock concert.

I am about to cycle off of ghkcu but I still have some left in vial. How long does it stay effective? Should I still use it after my 4 week break or should I get rid of it?