Okay can we talk about this đ© I have always had perfectly regular Bristol 4 stools every morning. On just a couple weeks with Reta, 500 mcg once a week, my stools still havenât normalized. It is making me has Bristol 5 -6 stools multiple times daily. How long has this taken others to normalize ? I donât have many other symptoms but I do feel the loss of appetite but no nausea etc. I donât want To up my dose until I have normal stools