Looking for some guidance- my 20 year old son has been battling eczema for the last couple of years. After a strict diet change (gf no dairy) some gut rebuilding and 1 cycle of GHK KPv - big improvement (almost fully cleared up). Took a 2 week break then restarted and it is now 10x worse. He trains 4x a week but his job (server) can be long hours and the sweat makes things worse.

Join me for our October Live Q&A on Saturday, October 25 at 12:00 p.m. EST. We’ll dig into peptides, mitochondrial medicine, training and recovery design, and real-world protocol troubleshooting. Bring your questions (big or small), wins, sticking points, and labs or metrics you want decoded. Come ready to learn, take notes, and leave with clear next steps you can use the same day. To submit a question in advance, reply to this post with “Q&A” at the top and a concise summary of your question; live questions will be taken in order after pre-submissions. Save the date, invite a friend who’d benefit, and I’ll see you Saturday at noon. Here is the link to watch the replay of the Q&A thank you everone for joining and thank you for sending your questions in! https://us06web.zoom.us/rec/share/pcj7EkP9JA9hgj2SIcHeiFFgml4klErn_CRj33Nbb10OM0gmzh7itR_vKyHGXXwd.Cs3mioaqFw2jbYHe?startTime=1761407862000 Passcode: e4T2tR!l

Most people have experienced it at some point: you sip your morning coffee or eat a rich, fatty meal, and within minutes you feel the urgent need to find a bathroom. What feels like a quirky reflex is actually a highly coordinated biochemical cascade that ties together gut chemosensors, mitochondrial redox signaling, and the autonomic nervous system. Understanding it not only explains the “coffee poops,” but also reveals a deeper logic about how the body manages energy, digestion, and balance. Coffee contains caffeine and chlorogenic acids, both of which stimulate gastrin and cholecystokinin (CCK). These hormones tell the stomach to empty faster and nudge the colon to get moving. Fatty foods add another layer: long-chain fatty acids in the small intestine trigger a surge of CCK, leading to gallbladder contraction (bile release) and pancreatic enzyme secretion. CCK also excites vagal afferents the gut’s way of phoning the brainstem to say, “Make room, something’s coming through.” The bile salts released to digest fats don’t just emulsify lipids. They also activate FXR and TGR5 receptors. TGR5 in particular lights up enteric neurons, ramping up motility. Pancreatic lipase breaks fats into free fatty acids and monoacylglycerols, which in turn hit GPR40/120 receptors, further fueling CCK and GLP-1 release. Meanwhile, caffeine blocks adenosine A1 receptors, removing a natural brake on motility and keeping cAMP signaling elevated. In essence, coffee and fats act like two friends teaming up one pushes down on the gas pedal, the other disables the brakes. Normally, digestion is a dance between the parasympathetic (rest-and-digest) and sympathetic (fight-or-flight) branches of the autonomic nervous system. Coffee and fats tilt that balance. Parasympathetic vagal activity spikes, releasing acetylcholine into the enteric nervous system, which activates M3 muscarinic receptors on gut smooth muscle. The result is strong peristalsis. Sympathetic tone temporarily relaxes, lowering sphincter control and letting the colon empty faster. The gastrocolic reflex, which is usually a subtle background process, gets supercharged. That’s why the urge can feel instantaneous.

Here’s a post that sets the tone for community-driven growth, sparks engagement, and positions you as a leader in both cellular medicine and strength training: Let’s Light the Fire: Learning Together in the Trenches One of the things I love most about this community is how committed we are—not just to learning, but to applying what we learn in the real world. So I’m dedicating this thread to all things education, training, and connection—online or in person. Whether it’s: An upcoming certification you’re excited about A seminar you’re hosting or attending Drop it here. Let’s build a living, breathing thread of learning opportunities for those serious about mastering cellular medicine, redox biology, strength, and systems thinking. I’ll kick things off with a few events I’ll be attending soon (posting those next). This is your invitation to: - Promote what you’re leading - Share what’s been valuable - Find your people to learn with—and from Whether you’re a practitioner, athlete, coach, or simply someone who thinks mitochondria deserve more respect you belong here. Tag someone you think should be at the next event with you.

👋 Hi, I’m Anthony Castore, SSRP Fellow, Strength Coach, and one of the few bridging elite performance with cutting-edge cellular medicine. With a background in peptide sciences, mitochondrial medicine, and advanced protocol design, I’ve helped high performers—from athletes to complex medical cases—reclaim their health, build unstoppable strength, and align biology with ambition. My work fuses rigorous science with real-world application—no fluff, no hype, just results. 🔑 Why This Community Exists This isn’t just my community—it’s yours. This is your training ground. Your lab. Your launchpad. Whether you’re here to optimize body composition, repair your gut, understand redox signaling, or finally crack the code on sustainable performance—this platform is built to empower you. The goal is simple:To help you become the star of your own story—and to equip you with the tools, knowledge, and frameworks to make clear, informed decisions rooted in science, lived experience, and real-time feedback. 📚 What You’ll Get Inside • Education that scales – From beginner-friendly breakdowns to advanced protocols rooted in systems biology and peptide pharmacology.• Discussion zones – Ask questions, share insights, and get direct input on supplementation, case studies, protocol design, and training periodization.• Office hours & mentorship access – Learn how the world’s top strength coaches and cellular medicine experts think, assess, and prescribe.• Ongoing content drops – Webinars, presentations, toolkits, and behind-the-scenes of real-world cases.• A true community – This isn’t a passive group. It’s an ecosystem of thinkers, doers, and seekers—supporting each other, growing together. 🚀 My Vision To build the most trusted education platform in performance medicine—one that empowers sovereign individuals to own their biology, train with precision, and age with intention. Not just to optimize, but to understand.Not just to do more, but to do better.And not just to follow protocols—but to design your own future with clarity and confidence.