Hey Peter! Glad you've created this community! Hello everyone! I am Edward Goeke, author of Contraindicated, and creator of many pieces of public material online that involves dismantling myths and falsehoods from a slew of health commentators online using fundamental biochemistry, physiology, and statistics to further reinforce and spread the message of carnivore to the world. I am also an instructor in Peter's CCI program, and I run my own Health Science community as well, which is for people that are keen on optimizing their health, want a place where the science is discussed plainly, without a hidden agenda, and have a deep curiosity into the workings of the human body and what that means for you on a day to day basis. We need more communities like this one that are based on scientific veracity, scientific rigor, truth, integrity, discipline, and hard science. Looking forward to speaking with all of you!

Yes, because any presentation (or "signal") is not due to one cause, but a multitude of different influencers acting simultaneously in a certain way. Think of any presentation as a food recipe. Think of heart disease as broccoli cheddar soup. There are a few ingredients that go into broccoli cheddar soup in order to actually yield the food. Those ingredients represent influences over heart disease. There are some ingredients that are more significant than others (such as the broccoli and the cheddar), meaning that those ones being removed have much more impact on how approximate the final result will be to the recipe you're attempting to make (remove the broccoli, the soup is nowhere near broccoli cheddar soup; remove the cheddar, same thing; remove both, you basically have nothing resembling it). Of course, in this scenario, the broccoli and the cheddar may represent chronic damage to tissue and cholesterol. Notice that if you remove the cholesterol, you won't get the plaque buildup, but that doesn't mean that cholesterol causes heart disease; That would be like saying that cheddar cheese causes broccoli cheddar soup. It doesn't make any sense. You need it for it, but you won't get it without broccoli too, or all of the other seasonings. Of course, the limitation with this analogy is that if you remove the broccoli and cheddar, you will never attain the aimed-for end result (broccoli-cheddar soup), while in the real world, the other extant or remaining ingredients when the most significant ones are removed may still end up forming the end result, just over a far slower period, which is my main point here. There are other influencers, just with varying strengths, therefore perhaps causing a slower rate of accumulation and/or formation, but not an elimination of the possibility of it.

@Melanie Spigelmyre 😂

Higher rates of fatty acid oxidation in fat cells directly causes an uncoupling of mitochondria and an increase in the amount, thus leading to increases density, considering density is simply mass divided by volume.

@James Dawkins Not entirely familiar with that, but it would not surprise me, considering fatty acid oxidation is necessarily a mitochondrial process, and therefore you must have sufficient resources to take on such a load of fatty acids that is seen in ketogenic states.

@Hrvoje Dominik Vidjak Usually this is measured the same way insulin resistance is "measured," which is by observing the area under the curve for insulin secretion, and especially comparing it to area under the glucose curve as well.

@Hrvoje Dominik Vidjak I'd have to peruse the literature a bit. Most studies I've observed have I:G ratios already measured as part of the study, not the studies themselves primarily focusing on that variable in isolation.

Live your best life. People will ask.

@Stephen Curtin Yes. Less talking, more doing. Unless you're me, or anyone else online, in which case it's a lot of both 😂