I definitely experience anhedonia as well. I had it with both Reta and Tirz but only as I raised the dose. If I keep the dose very low I’m okay. I believe it is related to dopamine and I do know that there are some peptides and can work on dopamine receptors. I haven’t tried any yet but it may be worth researching. I have also found that it gets worse if my calories are too low, if I’m not getting regular exercise (specifically cardio) and definitely if I’m not getting enough sleep so I have to be super diligent about those things. According to chatGPT (I know, we have to be careful and check chat’s answers!) the lowered dopamine comes primarily from the GIP aspect of both Tirz and Reta and so I’m wondering if Mazdutide (which I believe the Peptique will be carrying soon) might cause less anhedonia since it doesn’t include the GIP component and is just GLP-1 and Glucagon.🤷‍♀️

Agree with Shawna! I have traveled to Mexico with peptides still in powder form, reconstituted vials and preloaded syringes and have never had an issue with any of it! I out them in a cold case with ice packs and put them in my checked luggage and it’s never been an issue!

I do really think you will see movement quickly with body recomp on Reta! I am with everyone above… I really liked the way the appetite suppression worked much better on Reta than Tirz. On Reta I feel like I’m not ever compelled to eat but can always eat what I plan and what I need. I don’t have any aversion to food and still love to look up recipes and cook for my family. On Tirz I just really didn’t want anything to do with food at all! Even on the smallest dose! I saw very quick changes on Reta and had to back off because I was worried I was losing too much weight. I haven’t had any increased anxiety and I can be pretty prone to that. Since you have the Reta it might be worth a try and then you know Tirz is a great option if you don’t like it! Good luck!

@Sabrina Serna are you doing a different type of progesterone that isn’t oral? I just bumped my oral progesterone dose from 100 to 200mg to help with 3 am wake ups and noticed lots of bloating that isn’t my favorite!!!

@Sabrina Serna wow! That was enlightening! Okay! I’m going to ask my functional med doctor about going the suppository route! Also, do you have any more resources up your sleeve about estrogen and when to take it? I am on progesterone and testosterone but according to my doctor since my estrogen levels are still good on progesterone and I am still getting my monthly cycle she says I shouldn’t be on it. According to that video you just sent she disagrees! Just wondering if you know where I can go for more info on that! Thanks so much!!