MOTS-C: The Folate Problem Nobody Warns You About (And How to Fix It)
Derek Note: I feel like we've covered a lot of the well-known peptides and I want to do at least 1 post a day, going deeper in some side effects that pop up and how to mitigate them. I am a peptide nerd at heart and want to provide real value daily in the space. You guys support peptideprice.store I provide as much free info as possible. Drop a π₯ if you're excited for this series. Let's Jump Into The Folate Problem (I have seen 0 creators talk about this except Dr. Dean St. Mart s/o https://www.youtube.com/@Deanstm) Quick Recap: How MOTS-C Actually Works MOTS-C is a peptide encoded by your mitochondrial DNA that triggers your body to build MORE mitochondria (cellular power plants). But here's the key: it doesn't just "turn on" mitochondrial growth - it forces it through metabolic stress. The mechanism: MOTS-C blocks folate metabolism pathways, similar to how methotrexate works. When your cells detect this folate "stress," they activate survival pathways (like AMPK) that trigger mitochondrial biogenesis. Your body essentially thinks: "We're under metabolic stress, we need MORE power plants to survive." This is the entire mechanism - not a side effect. The folate blocking IS what creates the adaptation. You can't have the mitochondrial benefits without the folate depletion. It's like training: You stress the muscle β Body adapts by building more muscle. MOTS-C: You block folate β Body adapts by building more mitochondria. The problem: While your body is busy building new mitochondria, your actual folate levels are tanking. And those new mitochondria can't function without folate. Neither can your brain. The One Thing You Must Understand MOTS-C blocks folate to trigger mitochondrial growth - this is HOW it works. But blocked folate = depleted folate = brain fog, mood crashes, and fatigue. Most people feel amazing for 2 weeks, then wonder why they suddenly feel like shit. This is why. What Folate Does (Why This Matters)