For those of us who’ve already been experimenting with retatrutide through research-grade sources, Eli Lilly’s new Phase 3 data is basically official validation. The mainstream is finally catching up to what early adopters have been experiencing in real time: this compound is on a completely different level from the standard GLP-1/GIP agonists. 📊 The Phase 3 Numbers Are Wild (But Honestly… Not Surprising) The TRIUMPH-4 late-stage clinical trial showed: - ~28.7% average weight reduction over 68 weeks - Over 70 lbs lost on average at the highest dose - Almost 40% of participants dropped 30%+ of their total body weight - Significant improvements in knee osteoarthritis pain and functional mobility For anyone who's used retatrutide consistently, this lines up with lived experience:more aggressive fat loss, faster, and with a metabolic “drive state” you don’t get from GLP-1s alone. 🔬 Why It Outperforms GLP-1s Retatrutide is a triple agonist — GLP-1 + GIP + glucagon.This multi-pathway activation is what biohackers have been calling the “holy trinity” of metabolic modulation: - GLP-1 = appetite suppression + slower gastric emptying - GIP = enhanced insulin response + energy partitioning - Glucagon = increased fat oxidation + metabolic acceleration When all three are firing, you get that stacked effect that feels very different from semaglutide or tirzepatide. ⚠️ Side Effects & Tolerability (From Both Trial and Real-World Use) Lilly’s data highlights the same things many of us have seen firsthand: - Nausea, diarrhea, and early-cycle GI turbulence - A subset of users tapping out due to side effects - Some stopping because the weight loss was “too much, too fast” Nothing shocking — but definitely a reminder that dose ramping is everything with this compound. 📅 What’s Coming Next More Phase 3 readouts will continue through 2026, but if these results hold, retatrutide is going to completely reshape the metabolic-therapeutics landscape.

Your peptides are only as powerful as the terrain you give them. I’ve just dropped a brand-new master guide inside WORLD PEPTIDE RESOURCE HUB that breaks down all the vitamin & amino blends (Lipo-C, Lipo-B, Fat Blaster, Focus, Relaxation PM, Super Human, Hair/Skin/Nails) and exactly which peptides they pair best with for fat loss, focus, sleep, recovery, and beauty. If you’re running peptides but feel like you’re leaving results on the table, this is for you. 💉⚡️ 👉 Go to the Classroom tab in our Skool community and open“Vitamin & Amino Blends – The Missing Piece in Your Peptide Stack”Start with the Start Here lesson.