Scientists are now describing a skin–brain axis, similar to the gut–brain axis, where the skin and nervous system communicate through immune, hormonal, and neurological pathways.
New findings suggest the skin microbiome may influence psychological wellbeing. Higher levels of certain bacteria (such as Cutibacterium) were linked to lower stress and better mood, according to a study published in the British Journal of Dermatology .
The skin can produce neuroactive chemicals like cortisol and substance P in response to microbes or inflammation, which then send signals back to the brain, influencing sensations such as itch, pain, comfort, or calmness .
This field overlaps with neurocosmetics, which explores how neurotransmitters, neuropeptides, and sensory pathways affect skin health and ageing