Deeper dive on ANGPTL 3/8 · Set The Standard

Deeper dive on ANGPTL 3/8

Here's a closer look at how this works as well as the gateway of fat loss that takes place, synergistically working with GH.

Key pieces to note:

ANGPTL 3/8 works independently from the LDLR unlike statins and unlike PCSK9i's. The mechanism in which this occurs specifically is through Endothelial Lipase release.

ANGPTL 3/8 Suppresses EL.

When in a fed state, ANGPTL 3/8 is high.

This suppresses EL and inhibits it from hydrolyzing phospholipids on HDL-c & LDL-c.

When it's not suppressed, EL is activated and it processes VLDL remnants, therefore depleting the LDL-c precursor pool, ultimately reducing the amount of LDL-c. Again, this happens completely independently from the LDLR.

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