So what is DB? Design Biology or DB is my shorthand for this idea: biology looks less like an accident and more like an engineered system. It treats living things the way an investigator treats a complex artifact, by asking what the parts do, how the information is stored, and what it would take for the system to work at all. Hereâs the outline of what I mean. Design Biology starts with the universe and the body. I believe the universe is ordered, lawful, and finely tuned for life. I also see the human body as an integrated, goal-directed system. It has interlocking subsystems, error-checking, repair, feedback control, and layered information storage. When I look at things like DNA coding, cellular machines, embryonic development, and the way organs coordinate, I see the same patterns we see in designed systems: codes, constraints, interfaces, and control loops. Design Biology is also a method, not just a conclusion. It asks, âWhat is the mechanism that builds this?â âWhat information is required?â and âWhat must already exist for this to function?â It focuses on testable features such as information density, irreducible interdependence among parts, coordinated timing, and the fact that many biological functions work only when multiple components are present together. My stance, stated plainly: I think life and the major biological architectures point to real design rather than undirected chance. I see design as the best explanation for why complex biological systems are information-rich, tightly coordinated, and functional from the start. I see it as an alternative to biological evolution. Mainstream evolution explains diversity through mutation and natural selection over time. My issue is not that populations change or that selection happens. My issue is whether unguided processes can realistically generate the kind of new, integrated biological machinery we see, in which many parts must match and work together. The system depends on encoded instructions and regulation. In my view, the origin of that kind of functional information and coordinated architecture is the central question, and âchance plus selectionâ does not answer it at the level of mechanism.