MK-677 Protocol Advice: Split Dosing vs. Single Dose? (No Hunger Response Yet)

Jan 14 (edited) • Let's discuss anything here

Hey everyone,

Excited to join the community! I’m hoping to get some feedback on my current research/protocol, specifically regarding MK-677 dosing and timing.

I’ve been running MK-677 since December 30, 2025, following a 5 days on / 2 days off schedule. Here is how it has gone so far:

First 3 Days: Started with 10mg in the morning. Zero effect on hunger.
Next Phase: Upped the dose to 20mg in the morning. Still no change in appetite.

I am currently in a bulk, so I was actually hoping for the hunger side effects to help get the calories in. I come from an Intermittent Fasting background, so maybe my hunger signals are just suppressed, but I expected more of a kick. The only noticeable effect so far is that I feel more tired/lethargic, though I'm not 100% sure if that's the MK or just general fatigue.

Current Experiment: A few days ago, I switched to splitting the dose: 10mg in the morning and 10mg at night before sleep.

Questions for the group:

What do you think is the superior protocol? 20mg in one go, or the 10mg/10mg split?
Has anyone else experienced zero hunger on 20mg?
Does splitting the dose help mitigate the lethargy while keeping GH levels stable?

Context on other compounds: I also added 12.5mg Enclomiphene and 10mg AC-262 a few days ago. I haven't "felt" anything from these yet either, but I know it's early days.

Any shared experiences or feedback would be much appreciated. Thanks!

4 comments