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Oct '25 (edited) • Peptide Tips
⚡ Why Electrolytes Are CRITICAL When Taking GLP-1s, NAD+, and other Peptides
If you're on a GLP-1, NAD+, or other peptides and feeling off... your electrolytes are probably tanked.
Here's what's actually happening in your body:
The Depletion Effect
GLP-1 medications work by:
- Slowing gastric emptying = you eat and drink way less
- Reducing appetite dramatically
- Increasing fluid loss through various mechanisms
The result? You're consuming 40-60% fewer calories AND fluids, which means significantly less sodium, potassium, and magnesium coming in.
Why NAD+ and Peptides Make It Worse
NAD+ supplementation increases cellular energy production and metabolic processes, which:
- Burns through electrolytes faster during cellular ATP production
- Increases demand for magnesium (required for 300+ enzymatic reactions)
- Accelerates fluid turnover at the cellular level
Other peptides (BPC-157, TB-500, etc.) stimulate:
- Tissue repair and regeneration = higher mineral demands
- Increased cellular activity = more electrolyte utilization
- Enhanced metabolic processes = faster nutrient depletion
The Warning Signs You're Depleted:
- Brain fog and difficulty concentrating
- Persistent fatigue despite adequate sleep
- Muscle cramps or weakness
- Headaches (especially afternoon/evening)
- Heart palpitations or irregular rhythm
- Dizziness when standing
- Increased anxiety or irritability
What You Actually Need:
Not just water. Not just a sports drink.
The Big 3:
- Sodium: 3000-5000mg daily (yes, really)
- Potassium: 3000-4000mg daily
- Magnesium: 400-600mg daily (glycinate form is best
Pro tip: Pink Himalayan salt + electrolyte powder + magnesium supplement before bed = game changer.
Bottom Line
These medications and peptides are incredible tools, but they create a perfect storm for electrolyte depletion. Your body can't function optimally when it's running on empty.
You're not lazy. You're not weak. You're depleted.
Fix your electrolytes, fix your energy.
Who else has experienced this? Drop a comment if optimizing electrolytes changed the game for you. 👇
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⚡ Why Electrolytes Are CRITICAL When Taking GLP-1s, NAD+, and other Peptides
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