Oct 31 (edited) • Peptide Tips
🔬 SLU-PP-332: The "Exercise Mimetic" - But Lifestyle First
Deep Dive SLU-PP-332 - the compound everyone's calling an "exercise in a pill." The science is legit, but let me be clear upfront: This is NOT a replacement for actual training and lifestyle habits.
What Is It?
SLU-PP-332 is a synthetic compound that activates estrogen-related receptors (ERRs), particularly ERRα, which regulates mitochondrial biogenesis and energy metabolism. Despite the name, it has nothing to do with estrogen.
How it works: It activates the same metabolic pathways triggered by endurance exercise - turning on genes for energy expenditure, fat metabolism, and cellular repair.
The Research Results
In obese mice treated for 28 days: gained 10x less fat, lost 12% body weight, increased fatty acid oxidation by 25% - all while eating the same and not exercising more .
In normal-weight mice: ran 70% longer and 45% further than untreated mice.
Additional benefits seen in studies: improved cardiac function, reduced inflammation in aging kidneys, and neuroprotective effects.
Research Dosing (Research/Anecdotal)
⚠️ Important: SLU-PP-332 has not undergone human clinical trials. That said, here's what is being experimenting with:
Lower Range: 250mcg - 1mg daily
- Typical starting point
- Subtle metabolic effects
- Testing tolerance
Moderate Range: 5-10mg daily
- More noticeable effects reported
- Common maintenance dose
Mega Dosing: 20mg - 400mg daily
- Extreme high end
- All administered as oral capsules
- Used by aggressive self-experimenters
- Unknown safety profile at these doses
Note: Research in mice used 50mg/kg twice daily (significantly higher relative dose than most humans are using).
My Standpoint: Master The Basics FIRST
Before even considering SLU-PP-332, you need these dialed in:
✅ Training: 4-6 days/week consistently (resistance + cardio)
✅ Nutrition: Whole foods, adequate protein, proper calories
✅ Sleep: 7-9 hours nightly
✅ Stress Management: Not chronically fried
✅ Consistency: 80%+ adherence for 6-12 months minimum
Real exercise gives you what this compound can't:
- Neuromuscular adaptations
- Mental health benefits
- Functional capacity and skill
- Discipline and habit formation
When It MIGHT Make Sense
Only after lifestyle is optimized:
- Injury recovery when training is limited
- Aging populations with genuine mitochondrial decline
- Elite athletes stacking with perfect training/nutrition
- Physical limitations preventing normal exercise
- Performance optimization on top of solid fundamentals
Real Talk
Most people looking into SLU-PP-332 haven't maxed out what consistent training and nutrition would deliver naturally.
Don't be the person taking exotic compounds while skipping workouts and eating poorly. That's not optimization - that's avoiding the real work.
This compound could be a useful tool for the right person at the right time. But 95% of people would get better results just training harder and eating better for 6 months straight.
Bottom Line
The science is fascinating. ERR activation may have real therapeutic potential for metabolic disease. But view this as a potential enhancer on top of an already-solid foundation - not a shortcut around the fundamentals.
Build the base first. Then optimize if it makes sense.
What's your take? Legitimate optimization tool or distraction from the basics? 👇
Disclaimer: Educational purposes only. Not FDA approved. Not medical advice. Research compounds carry risks.
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🔬 SLU-PP-332: The "Exercise Mimetic" - But Lifestyle First
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