Oct 30 (edited) • Peptide Tips
💡 NAD+ vs NAD+ Buffered - What are the Differences?
Hey everyone! Let's talk about the difference between regular NAD+ and buffered NAD+ peptides.
Regular NAD+ Peptide:
- Highly acidic when reconstituted (pH around 2-3)
- Known for causing significant injection site pain and burning
- Can feel like "liquid fire" going in - especially subQ
- IV infusions often cause the "NAD flush" - chest tightness, facial flushing, discomfort
- Nasal spray versions can irritate and burn nasal passages
- Some people experience nausea or systemic discomfort during administration
NAD+ Buffered Peptide:
- Contains buffering agents (sodium bicarbonate or phosphate buffers)
- pH adjusted to near-physiological levels (6.5-7.5)
- DRAMATICALLY reduced injection site pain
- Much smoother, more comfortable injections (subQ or IM)
- Significantly less "flush" during IV administration
- Better tolerated in nasal spray form
- Way easier to stick with long-term protocols
The Real Difference: Both deliver the same NAD+ molecule and have similar efficacy. The buffered version is simply formulated to match your body's natural pH, making it FAR more comfortable to administer.
Bottom Line: If you've avoided NAD+ because of horror stories about injection pain, or if you've tried it and couldn't handle the discomfort - buffered is your answer. It's the same benefits without the torture.
Running NAD+ in your stack? Which version are you using? Drop your experiences below! 👇
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💡 NAD+ vs NAD+ Buffered - What are the Differences?
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