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2d (edited) • Peptide Tips
How 5-Amino-1MQ Actually Works: The Metabolic Brake Release 🔓
Quick breakdown of what 5-Amino-1MQ does in your cells and why it matters for fat loss and metabolism. We talked about NAD+ yesterday, full substack post here: How NAD+ Actually Works
What 5-Amino-1MQ Does (The Simple Version)
5-Amino-1MQ is a molecule that blocks an enzyme called NNMT (Nicotinamide N-Methyltransferase).
Think of NNMT as a metabolic brake that:
- Destroys NAD+ building blocks
- Slows down your metabolism
- Promotes fat storage
- Gets MORE active as you gain weight
5-Amino-1MQ removes that brake.
Understanding NNMT (The Problem)
NNMT does three harmful things:
1. Wastes NAD+ Precursors
- Takes nicotinamide (NAD+ building block)
- Adds a methyl group to it
- Creates 1-MNA (useless molecule)
- You literally pee out your NAD+ potential
2. Steals Methyl Groups
- Uses SAMe (critical for DNA, neurotransmitters, detox)
- Depletes this essential resource
- Impairs cellular function
3. Slows Metabolism
- High NNMT = reduced fat burning
- Decreases thermogenesis (heat production)
- Promotes fat storage mode
- Makes weight loss harder
The cruel cycle: Being overweight → More NNMT expression → Harder to lose weight → More weight gain → Even more NNMT
How 5-Amino-1MQ Works
STEP 1: Blocks NNMT
- 5-Amino-1MQ mimics nicotinamide structurally
- Binds to NNMT's active site
- NNMT can't destroy NAD+ precursors anymore
STEP 2: Preserves NAD+ Production
- Nicotinamide stays available
- Gets recycled back into NAD+
- NAD+ levels increase (indirectly)
STEP 3: Preserves Methyl Groups
- SAMe isn't wasted on NNMT
- Available for critical functions
- Better gene expression and neurotransmitter production
STEP 4: Metabolic Shift
- Fat cells switch from storage to burning mode
- Increased thermogenic gene expression
- Enhanced mitochondrial function in fat tissue
- Body prefers burning fat for energy
The Fat Loss Process
What happens when NNMT is blocked:
Week 1-2: Cellular Reprogramming
- Fat cells start changing their gene expression
- Thermogenic pathways activate
- Metabolic flexibility improves
Week 3-4: Metabolic Shift
- Body preferentially burns fat for fuel
- Increased lipolysis (fat breakdown)
- More fatty acids released into bloodstream
Week 6-8: Visible Results
- Noticeable fat loss (especially visceral)
- Better energy from fat oxidation
- Improved body composition
Week 10-12: Significant Change
- Substantial fat reduction
- Metabolic rate improvement
- Sustained energy levels
The Energy Source Difference
Traditional approach: Restrict calories, force fat burning
5-Amino-1MQ approach: Remove metabolic brake, body naturally prefers fat as fuel
What this means:
- You're not starving yourself
- Your body WANTS to burn fat
- Energy comes from stored fat reserves
- Metabolic flexibility restored
It's like switching your car's fuel preference from regular to premium - and the premium is stored in your own tank.
Research Findings
Animal studies (mice):
- 7% body weight reduction in 11 days
- 30% reduction in white adipose tissue
- 60% increase in NAD+ levels in fat tissue
- No change in food intake required
- No observed side effects
Mechanism confirmed:
- Mice without NNMT (genetic knockout) were lean and obesity-resistant
- Blocking NNMT with 5-Amino-1MQ replicated the same effect
- Proved NNMT is a legitimate metabolic target
Beyond Fat Loss
5-Amino-1MQ also:
- Increases NAD+ availability (by preventing waste)
- Preserves SAMe for critical functions
- Improves mitochondrial function in adipose tissue
- Reduces inflammation (fat tissue is inflammatory)
- Enhances metabolic flexibility
The result: Better overall metabolic health, not just weight loss.
The Bottom Line
5-Amino-1MQ blocks NNMT, an enzyme that:
- Destroys NAD+ building blocks
- Slows your metabolism
- Promotes fat storage
By removing this brake, your body:
- Preserves more NAD+
- Shifts to preferring fat as fuel
- Burns stored fat more efficiently
- Increases metabolic rate
You're not forcing fat loss - you're removing what was preventing it.
Read the complete breakdown here: 👉 How 5-Amino-1MQ Actually Works: Full Article
Questions? Drop them below 👇
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How 5-Amino-1MQ Actually Works: The Metabolic Brake Release 🔓
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