This is where most researchers mess up.
They hit their goal, feel great, and then just... stop. Cold turkey.
A few weeks later? Food noise is screaming. Hunger is through the roof. The scale starts creeping back up.
And they think something's wrong with them.
It's not you. It's biology.
When you stop a GLP-1 abruptly, your body fights back:
→ Ghrelin (hunger hormone) can surge above your original baseline
→ GLP-1 receptors upregulate and "want" stimulation
→ Gastric emptying speeds back up so meals don't hold you
The good news? This is avoidable.
I just dropped a full breakdown on Substack covering:
✓ What GLP-1s are actually doing in your brain, gut, and pancreas
✓ Why cold turkey backfires (the mechanisms behind it)
✓ How to properly titrate down (with a real example from 8mg tirz)
✓ Why you need 4 weeks at each dose (it's pharmacokinetics, not arbitrary)
✓ What "true maintenance" actually looks like (hint: it's a range, not a number)
✓ Signs you've found your maintenance sweet spot
If you're approaching your goal weight or already there and thinking about what's next — read this before you make any changes.
Drop any questions below. 👇