Can't Sleep on Tirz or Reta? Try This Simple Fix 😴
If you're struggling with sleep quality while researching GLP-1s like tirzepatide or retatrutide, here's something that helped me and many others:
Push your last meal 3-4 hours before bedtime.
Why This Works (The Science Made Simple)
GLP-1 receptor agonists work partly by slowing down gastric emptying - basically, your stomach takes longer to process and move food into your intestines. This is actually one of the mechanisms that helps with satiety and weight management.
But here's the problem: when you eat close to bedtime while on these peptides, your digestive system is still working overtime while you're trying to sleep. Your body is:
  • Actively digesting food (which requires energy and blood flow)
  • Dealing with potential acid reflux from food sitting in your stomach longer
  • Experiencing blood sugar fluctuations as nutrients slowly absorb
  • Staying in a more "active" metabolic state instead of rest mode
All of this can seriously impact your deep sleep - the restorative stage where your body does most of its repair work and growth hormone release happens.
The Fix
Stop eating 3-4 hours before bed. Give your stomach time to empty and your body time to shift into proper rest mode.
You'll likely notice:
  • Falling asleep faster
  • Better deep sleep quality (check your sleep tracker if you have one)
  • Less middle-of-the-night wake-ups
  • Reduced morning grogginess
This one simple timing adjustment has been a game-changer for sleep quality while researching these compounds. Your body will thank you.
Anyone else notice improved sleep with earlier last meals? Drop your experience below 👇
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Derek Pruski
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Can't Sleep on Tirz or Reta? Try This Simple Fix 😴
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