Dec '25 ā¢ Muscle Building
šŖš»šš§¬ IGF-1 LR3 & PEG-MGF
IGF-1 LR3 and PEG-MGF Injection Demo: Targeting Biceps and Delts for Growth
Hey Peptide Bio Hack Research Hub community! In this video, Iām sharing my site-specific injection routine with IGF-1 LR3 and PEG-MGF, focusing on biceps and delts to test localized muscle growth. As always, these are research peptidesānot for human useāso this is for educational purposes only. If youāre new to peptides, letās break down what they do, why they might help, how they work, and the realities from studies. Iāll tie in my experience over the past month-plus.
What is IGF-1 LR3 and Why Use It?
IGF-1 LR3 is a modified version of insulin-like growth factor-1, a natural hormone the body produces in response to growth hormone (GH). The āLR3ā extension makes it last longer (up to 20-30 hours vs. natural IGF-1ās minutes), allowing sustained effects. It promotes muscle growth by activating satellite cells (stem-like cells that fuse to muscle fibers for repair and enlargement) and boosting protein synthesisāthe process where cells build new proteins for tissue. Studies in animal models show IGF-1 LR3 increases muscle mass by 10-20% over 4-6 weeks when injected locally, as it enhances nutrient uptake and cell proliferation right at the site. In human research (limited, mostly anecdotal from bodybuilding), itās used pre/post-workout to amplify training gains without systemic sides like low blood sugar at low doses (20-50 mcg). Why? It mimics the bodyās response to heavy lifting, potentially speeding hypertrophy (muscle size increase) in targeted areasāideal if youāre addressing imbalances, like my right bicep lagging from a February car accident that sidelined it for months.
What is PEG-MGF and Why Use It?
PEG-MGF (pegylated mechano growth factor) is a variant of IGF-1 released during muscle stress, like after workouts. The āPEGā attachment extends its half-life (days vs. hours), making it more effective for recovery. It works by stimulating myoblast (young muscle cell) proliferation and reducing inflammation, helping repair micro-tears from training. Preclinical studies on rodents show PEG-MGF accelerates muscle healing by 15-25% post-injury, promoting fiber regeneration through pathways like PI3K/Akt for cell survival. In human contexts (mostly from athlete reports), itās injected post-workout to localized sites for better rebuildādoses like 100-300 mcg per muscle support this without broad effects. Why? It targets mechanical damage, complementing IGF-1 LR3 for a ārepair and growā combo, potentially yielding 20-30% better gains in stacked protocols per muscle biopsy research.
How They Work Together: The Realities and Clinical Insights
In the video, I demo pre-workout IGF-1 LR3 (20 mcg per bicep) to prime for growth during lifts, post-workout PEG-MGF (125 mcg per delt and bicep) for repair, and another IGF-1 LR3 (20 mcg per bicep) to extend the anabolic window. This site-specific approach leverages how these peptides act locally: IGF-1 LR3 binds receptors to drive hypertrophy, while PEG-MGF focuses on proliferationāanimal trials show combining them boosts muscle cross-section 25-40% more than alone. Realities: Benefits arenāt guaranteedāhuman clinical trials are limited (mostly on IGF-1 for growth deficiency, showing safe 10-20% lean mass gains at low doses), and results depend on training/diet. Sides like injection pain or retention are rare at these levels (5-10% incidence), but monitor. Not magicāexpect gradual changes over 4-8 weeks.
My Experience: Consistent Use and Early Results
Iāve done this on workout days for over a monthāonly in biceps/delts to test growth. Photos from before I started the combo (November 7th) and then photos from about 6 weeks of using (December 27) show noticeable bicep gains, especially my right (previously smaller from accident recovery). Canāt pinpoint exact worth vs. cost yetāusing remaining (another PEG vial, two IGF)ābut if growth continues, itās promising. For new users: Start low (10-20 mcg IGF, 100 mcg PEG), use sterile technique, and track with measurementsāliterature emphasizes consistency for measurable hypertrophy.
What do you think? Tried site-specific pinning? Share below!
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šŖš»šš§¬ IGF-1 LR3 & PEG-MGF
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