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Josh holyfield: Why Your Liver Enzymes Look Bad on a Standard Blood Panel If you go to your doctor and you see these elevated liver enzymes and you don't tell them you're on RETA, he's going to freak out. And that reaction makes sense from his side of the desk, because on a standard panel the only two liver markers most doctors order are AST and ALT, and when those come back high the first thing a physician thinks about is alcohol, fatty liver, or hepatitis. He is not thinking about a guy who deadlifted heavy three days ago and is running a peptide he did not disclose. So before you panic about a number on a page, understand what those two enzymes actually are. AST and ALT are enzymes that live inside cells, and when a cell gets damaged or stressed, it leaks them into your blood, with ALT sitting mostly in liver tissue while AST spreads across the liver, the skeletal muscle, and the heart. That second part is the whole reason this gets misread. Now, one thing to note, right, is if you're actively in the gym, you're training really hard, you're going to see those numbers elevated. When you put a muscle under enough mechanical tension to grow it, you also cause enough microdamage for those enzymes to spill out into circulation, and the lab has no way to tell whether that AST came from your liver or your quads. Blood markers used to track training load are routinely elevated in athletes because of muscle turnover, not organ disease, which is exactly why sports medicine treats athlete reference ranges differently than sedentary ones Retatrutide Raising Your Liver Enzymes? Why You Need a GGT Test Josh Holyfield 🔥 2h • General discussion Retatrutide Raising Your Liver Enzymes? Why You Need a GGT Test Why Your Liver Enzymes Look Bad on a Standard Blood Panel If you go to your doctor and you see these elevated liver enzymes and you don't tell them you're on RETA, he's going to freak out. And that reaction makes sense from his side of the desk, because on a standard panel the only two liver markers most doctors order are AST and ALT, and when those come back high the first thing a physician thinks about is alcohol, fatty liver, or hepatitis. He is not thinking about a guy who deadlifted heavy three days ago and is running a peptide he did not disclose.