I have found my ADHD meds really help with my PTSD symptoms and issues as well. The research I have done shows that ADHD and PTSD issues are very similar. Both can involve dysregulation of the nervous system, difficulty concentrating, intrusive thoughts, heightened startle responses, emotional impulsivity, and an overactive fight-or-flight instinct. This instinct affects how the brain processes threats, memory, and executive function.
I have discovered that a lot of my brain freeze and disassociation comes from cortisol and adrenalin. While necessary and helpful even when faced with an imminent threat, my issue comes when the cortisol and adrenalin "throttle" gets stuck wide open, and my fight or flight just won't stop so I can think rationally. This can also happen due to a lack of Vitamin D, Vitamin B6, B12, magnesium, zinc, and omega-3 fatty acids, which are all connected to mood regulation, neurotransmitter balance, and cognitive function. As someone with ADHD, Vitamin D deficiency is normal, as is magnesium, zinc, and omega-3 deficiency.
Vitamin D plays a role in producing serotonin and dopamine, neurotransmitters essential for mood stability and focus. Low levels have been associated with increased anxiety, emotional dysregulation, and “foggy thinking.” Because it influences inflammatory responses in the brain, a deficiency may contribute to heightened stress sensitivity and an exaggerated fight-or-flight response.
Vitamin B6 is required for the synthesis of GABA, dopamine, and serotonin—neurotransmitters that regulate calmness, emotional control, and executive function. Low levels may contribute to intrusive thoughts, irritability, poor stress tolerance, and difficulty concentrating because the brain doesn’t have the chemical balance to switch gears or regulate reactions effectively.
Vitamin B12 supports the myelin sheath that insulates and protects nerves; without it, communication between nerve cells slows. Deficiency may manifest as cognitive fog, memory problems, slow processing, or heightened emotional reactivity. Because it also supports energy metabolism, low B12 can make the brain feel like it is “underpowered” during stress.
Magnesium influences the parasympathetic nervous system—the “rest and recover” counterpart to fight-or-flight. It helps regulate cortisol and supports muscles and nerves in calming after activation. Low magnesium is commonly associated with difficulty relaxing, sleep disturbances, tense muscles, exaggerated startle reflex, and stress-triggered impulsivity.
Zinc plays a role in regulating the stress response and supporting brain signaling pathways connected to memory and emotional control. A deficiency can impair how the brain quiets an unnecessary threat signal, which may contribute to looping thoughts, irritability, or sensitivity to environmental triggers.
Omega-3s, particularly DHA and EPA, are structural components of the brain and are essential for efficient neurotransmitter signaling. Low omega-3 levels may contribute to poor attention regulation, impulsivity, mood instability, and difficulty transitioning out of fight-or-flight because the brain’s communication pathways are less flexible and resilient under stress.
These nutrients are necessary for normal operation of the brain and body. ADHD medication cannot make up for the lack of these nutrients. Additionally:
5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid which serves as a building block the body uses to produce serotonin, a neurotransmitter involved in mood regulation, impulse control, sleep, memory, and emotional processing. Because serotonin influences how the nervous system responds to stress and stimulation, 5-HTP can play a role in controlling dysregulation, difficulty concentrating, intrusive thoughts, heightened startle responses, emotional impulsivity, and an overactive fight-or-flight instinct.
By supporting serotonin production, 5-HTP may help with emotional steadiness, reduce looping thoughts or worry, improve focus by balancing dopamine and executive functioning, calm exaggerated fear responses, and assist the brain in shutting off the threat response when danger has passed.
However, because it can increase serotonin levels, 5-HTP may interact with prescription medications that affect serotonin, including SSRIs, SNRIs, MAOIs, migraine medications, and certain supplements, so it is important to approach its use cautiously.
L-Theanine is an amino acid commonly found in green tea that is known for promoting a state of calm focus without causing drowsiness. It supports the brain’s production of GABA, dopamine, and serotonin—neurotransmitters involved in relaxation, attention, emotional regulation, and stress recovery. Because of its ability to increase alpha brain waves, which are associated with a relaxed but alert mental state, L-Theanine may play a role in reducing emotional impulsivity, quieting intrusive thoughts, easing an overactive startle response, and helping the brain transition out of fight-or-flight mode. Many people explore it for its potential to smooth out nervous system dysregulation, improve concentration during stress, and support cognitive clarity without the caffeine “crash.”
Ashwagandha is an adaptogenic herb traditionally used in Ayurvedic medicine to help the body regulate stress by supporting the adrenal system and balancing cortisol production. Because cortisol is directly connected to the brain’s threat response, emotional stability, and ability to shift out of fight-or-flight mode, Ashwagandha may assist with emotional impulsivity, heightened startle response, and difficulty relaxing after stress. People often explore it for calming nervous system overactivation, mental fatigue, and sleep issues that stem from chronic stress overload.
Rhodiola Rosea is another adaptogen known for its role in supporting energy, stamina, and cognitive function, particularly in situations involving prolonged stress or burnout. Rather than calming the nervous system like Ashwagandha, Rhodiola is often described as helping improve mental clarity, concentration, and emotional resilience by supporting the brain’s stress-response pathways. It is commonly explored for intrusive thoughts, difficulty concentrating, and the sense of cognitive shutdown that may occur when the stress-response system is overwhelmed.
Panax Ginseng is an adaptogenic herb traditionally used to support energy, mental clarity, and resilience to stress. It works by modulating the nervous system and supporting balanced cortisol and adrenaline responses, which can help prevent the fight-or-flight system from becoming overactive. Panax Ginseng can contribute to improved concentration, reduced mental fatigue, and enhanced cognitive function under stress, while also supporting emotional stability and resilience to intrusive thoughts. Because of its energizing effects, it can complement calming herbs like L-Theanine or Ashwagandha, helping the brain maintain focus and alertness without exacerbating stress-related nervous system dysregulation.
St. John’s Wort is an herbal supplement traditionally used to support mood regulation by influencing the brain’s serotonin, dopamine, and norepinephrine systems. By helping balance these neurotransmitters, it can play a role in reducing emotional dysregulation, intrusive thoughts, and mild anxiety, while supporting more stable focus and cognitive function. It can also help temper the overactive fight-or-flight response by promoting a calmer, more resilient nervous system. However, St. John’s Wort can interact with many medications—including antidepressants, birth control, blood thinners, and certain seizure or heart medications—so it should be used cautiously and under guidance.