Sep '24 • 💡Research & Education
An update on my research - so far
I've been looking into the various drugs/supplements that can help in the fight against cancer.
I've been Googling, using AI, and reading various studies and started to create a list. It got fairly long and when I started looking through the Classroom Content here, it got longer.
I though this might help some of you since this has taken many hours over several days of reading and checking to put together. Though I am no doctor, I am pretty good at research. Please, take nothing in this list at face value. Do your own checking.
All of the supplements with an * are also listed in the protocol from Dr Seyfried.
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Repurposed Drugs & Supplements
My research into natural anticancer supplements that will help destroy cancer cells and inhibit their growth.
I have found a website in China (extractspowder.com), but I have not done any research yet to see how good they are, though if they do check out okay, their pricing is very attractive at first glance. If you use these links to purchase, please do your own due diligence. This is not a recommendation.
Curcumin*
Frontiers | Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells (frontiersin.org)
Find a curcumin with piperine to enhance absorption if possible.
Shown in a study to inhibit cancer growth by 40%
Curcumin has been extensively studied for its potential anticancer properties. Here are some key points:
- Inhibition of Carcinogenesis: Curcumin can interfere with the process of carcinogenesis, which is the formation of cancer. It does this by affecting various molecular pathways involved in the initiation, promotion, and progression of cancer.
- Anti-inflammatory and Antioxidant Effects: Chronic inflammation and oxidative stress are known to contribute to cancer development. Curcumin has strong anti-inflammatory and antioxidant properties, which help reduce inflammation and neutralize free radicals, potentially lowering cancer risk.
- Induction of Apoptosis: Curcumin can induce apoptosis (programmed cell death) in cancer cells without affecting normal cells. This selective action makes it a promising compound for cancer therapy.
- Inhibition of Angiogenesis: Angiogenesis is the process by which new blood vessels form, supplying nutrients to tumors and allowing them to grow. Curcumin can inhibit angiogenesis, thereby starving the tumor of necessary nutrients.
- Enhancement of Chemotherapy and Radiotherapy: Some studies suggest that curcumin can enhance the effectiveness of chemotherapy and radiotherapy, making cancer cells more susceptible to these treatments while reducing their side effects.
- Reduction of Metastasis: Curcumin has been shown to reduce the spread of cancer cells to other parts of the body (metastasis) by affecting various signaling pathways involved in cell migration and invasion.
Piperine
Piperine is a kind of alkaloid extracted from pepper fruit. High-purity piperine is needle-shaped or short rod-shaped light yellow or white crystal powder. Resent medical studies have shown piperine to be very helpful in increasing the absorption of certain vitamins such as Selenium, Vitamin B and Beta-Carotene. --and curcumin.
Research indicates that piperine has several mechanisms that may contribute to its anticancer effects. These include:
- Inhibition of Cancer Cell Proliferation: Piperine can inhibit the growth of various cancer cells by interfering with their cell cycle and inducing apoptosis (programmed cell death).
- Anti-Metastatic Effects: It has been shown to reduce the migration and invasion of cancer cells, which are crucial steps in the metastasis process.
- Modulation of Signaling Pathways: Piperine affects several signaling pathways involved in cancer development, such as STAT-3, NF-κB, and PI3K/Akt pathways.
- Enhancement of Chemotherapy: Piperine can enhance the efficacy of certain chemotherapy drugs, making cancer cells more susceptible to treatment.
Resveratrol*
Resveratrol is a naturally occurring polyphenolic compound found in various plants, including grapes, berries, and peanuts. It’s also present in red wine. This compound has garnered significant attention for its potential health benefits, including its anticancer properties.
Anticancer Benefits of Resveratrol
- Induction of Apoptosis: Resveratrol can trigger apoptosis (programmed cell death) in cancer cells by affecting mitochondrial functions and increasing oxidative stress within these cells1.
- Cell Cycle Regulation: It can interfere with the cell cycle of cancer cells, preventing them from proliferating.
- Anti-inflammatory Effects: Chronic inflammation is a known risk factor for cancer. Resveratrol has anti-inflammatory properties that can help reduce this risk.
- Inhibition of Angiogenesis: Resveratrol can inhibit angiogenesis, the process by which new blood vessels form, which is crucial for tumor growth and metastasis.
- Enhancing Chemotherapy: It has been shown to increase the sensitivity of cancer cells to chemotherapeutic drugs, potentially making treatments more effective.
- Antioxidant Properties: By activating the Nrf2 signaling pathway, resveratrol can enhance the expression of antioxidant genes, protecting cells from oxidative damage.
Currently, there is no universally established dose for anticancer purposes in humans, as most studies have been conducted in vitro (in the lab) or in animal models.
General Guidelines and Considerations
- Clinical Trials and Studies: Some clinical trials have used doses ranging from 250 mg to 5 grams per day of resveratrol, but these studies often focus on general health benefits rather than specific anticancer effects.
- Bioavailability: Acetyl Resveratrol is a modified form of resveratrol designed to improve bioavailability. This means it might be more effective at lower doses compared to regular resveratrol.
- Consultation with Healthcare Providers: It’s crucial to consult with a healthcare provider before starting any new supplement, especially for anticancer purposes. They can provide personalized advice based on your specific situation.
- Potential Side Effects: High doses of resveratrol can cause side effects such as gastrointestinal issues, and its interaction with other medications should be carefully monitored.
Current Research Insights
- In Vitro and Animal Studies: Research has shown that resveratrol can inhibit cancer cell growth and induce apoptosis at various concentrations, but translating these findings to human doses requires more research.
- Human Studies: Limited human studies suggest that doses up to 5 grams per day are generally well-tolerated, but the optimal dose for anticancer effects is still under investigation.
Glutamine Inhibitors
- green tea: contains EGCG, which inhibits an enzyme, glutamate dehydrogenase, that helps cancer cells use glutamine
- ashwaghanda: contains the enzyme L-asparaginase, which keeps you from digesting glutamine. Make a relaxing tea from it.
- seeds of fresh peppers: All peppers from the capsicum annum family, including the large sweet bells and many smaller pungent peppers, contain L-asparaginase, especially in their seeds. (If you don’t have cancer, however, avoid a steady diet of pepper seeds due to your body’s need for glutamine.)
Epigallocatechin gallate – EGCG - (Green Tea)*
A major component of green tea, it has been shown to inhibit both PI3K and mTOR.
Epigallocatechin gallate (EGCG) is a type of catechin, which is a natural phenol and antioxidant found predominantly in green tea. It is known for its numerous health benefits, including its potential anticancer properties.
Anticancer Properties of EGCG
- Anti-Proliferative Effects: EGCG can inhibit the growth and proliferation of cancer cells by interfering with various signaling pathways that are crucial for cell division and survival.
- Pro-Apoptotic Effects: It promotes apoptosis (programmed cell death) in cancer cells, which helps in reducing the number of malignant cells.
- Anti-Angiogenic Effects: EGCG can inhibit angiogenesis, the process by which new blood vessels form from pre-existing ones. This is significant because tumors need a blood supply to grow and spread.
- Epigenetic Modulation: EGCG has been shown to affect the expression of genes involved in cancer through epigenetic mechanisms, such as DNA methylation and histone modification. This can lead to the suppression of oncogenes (genes that can transform a cell into a tumor cell) and the activation of tumor suppressor genes.
- MicroRNA Regulation: EGCG can modulate the expression of microRNAs, which are small non-coding RNAs that play a role in gene regulation. This modulation can lead to the suppression of cancer cell growth and metastasis.
- Antioxidant and Anti-Inflammatory Effects: By reducing oxidative stress and inflammation, EGCG helps in creating an environment that is less conducive to cancer development.
EGCG’s multifaceted approach in targeting cancer cells makes it a promising compound for cancer prevention and therapy.
Berberine*
A compound found in various plants, it has shown PI3K and mTOR inhibitory effects.
Research has shown that berberine has several potential anticancer properties:
- Inhibits Cancer Cell Growth: Berberine can induce apoptosis (programmed cell death) and control the cell cycle, which helps prevent the proliferation of cancer cells.
- Reduces Inflammation: Chronic inflammation is a known risk factor for cancer. Berberine has anti-inflammatory properties that can help reduce this risk.
- Boosts Immune Response: It enhances the immune system’s ability to fight cancer by activating macrophages and other immune cells.
- Blocks Key Pathways: Berberine can block pathways like Akt and mTOR, which are involved in cancer cell survival and growth, while promoting AMPK, which helps weaken cancer cells.
- Acts as a Chemo- and Radio-sensitizer: It can enhance the effectiveness of chemotherapy and radiotherapy by making cancer cells more sensitive to these treatments.
- Prevents Metastasis: Berberine hinders tumor cell invasion and metastasis by down-regulating proteins related to metastasis.
The safe dosage of berberine can vary depending on the specific product and individual factors such as age, weight, and overall health. However, general guidelines for berberine supplementation are as follows:
General Dosage Guidelines
- Typical Dosage: For most adults, a common dosage is between 500 mg to 1500 mg per day, divided into 2-3 doses.
- Starting Low: It’s often recommended to start with a lower dose, such as 500 mg per day, to assess tolerance and then gradually increase.
- Duration: Berberine is usually taken for a period of 8-12 weeks. Long-term use should be monitored by a healthcare provider.
Potential Side Effects
- Gastrointestinal Issues: Some people may experience digestive issues such as constipation, diarrhea, or stomach cramps.
- Interaction with Medications: Berberine can interact with certain medications, including those for diabetes and high blood pressure.
Chinese Goldthread Extract 97% Berberine Hycholoride,Berberine,Berberine powder (extractspowder.com)
Kaempferol
In normal cells, kaempferol and quercetin act as anti-oxidants and neutralize free radicals of oxygen, which would otherwise damage cells. But in cancer cells, K and Q behave entirely differently. Instead, they act as pro-oxidants, creating free radicals of oxygen, which in turn damages cancer cells and forces them to self-destruct. (Curcumin in turmeric, EGCG in green tea and melatonin also do that.)
SOURCES OF KAEMPFEROL
- Green Tea Extract: Green tea is a well-known source of kaempferol and other beneficial flavonoids.
- Broccoli Extract: Broccoli and other cruciferous vegetables are high in kaempferol.
- Ginkgo Biloba Extract: This herbal supplement also contains significant amounts of kaempferol.
- Capers: Capers are one of the richest sources of kaempferol among foods.
CAS No.: 520-18-3 Kaempferol,98% Kaempferol,Plant extract Kaempferol,Kaempferol powder (extractspowder.com)
Quercetin*
Quercetin is a plant flavonoid commonly found in many fruits, vegetables, and grains. It’s known for its antioxidant, anti-inflammatory, and anticancer properties.
Anticancer Properties of Quercetin
Quercetin has shown potential in cancer prevention and treatment through several mechanisms:
- Inhibition of Tumor Growth: Quercetin can inhibit the proliferation of cancer cells and induce apoptosis (programmed cell death) in various types of cancer.
- Anti-Metastatic Effects: It helps prevent the spread of cancer cells to other parts of the body by inhibiting invasion and metastasis.
- Modulation of Signaling Pathways: Quercetin affects multiple signaling pathways involved in cancer progression, such as the PI3K/Akt, MAPK, and Wnt/β-catenin pathways.
- Antioxidant Activity: By scavenging free radicals, quercetin reduces oxidative stress, which is linked to cancer development.
- Regulation of Gene Expression: It can modulate the expression of genes involved in cell cycle regulation and apoptosis.
For general health benefits, quercetin supplements are often taken in doses ranging from 500 mg to 1,000 mg per day. When it comes to anticancer purposes, studies have explored various dosages, but there isn’t a universally recommended dose due to the complexity and variability of cancer treatments.
Considerations for Anticancer Use
- Consultation with Healthcare Providers: It’s crucial to consult with a healthcare provider before starting any supplement regimen, especially for cancer treatment.
- Combination with Other Treatments: Quercetin is sometimes used in combination with other treatments, which can influence the appropriate dosage.
- Individual Factors: Factors such as the type of cancer, stage of the disease, overall health, and other medications being taken can affect the optimal dosage.
Research Insights
Some studies have used doses up to 1,000 mg to 2,000 mg per day in divided doses for anticancer effects. However, these studies are often preliminary, and more research is needed to establish safe and effective dosages.
Safety and Side Effects
High doses of quercetin can cause side effects such as headaches, stomach upset, and kidney damage if taken in excessive amounts over long periods.
Ursolic acid*
Ursolic acid is a natural compound found in various plants, including rosemary (Rosmarinus officinalis). It is a type of triterpene acid known for its potential health benefits, including anti-inflammatory, antioxidant, and anticancer properties.
Rosemary extract, which contains ursolic acid along with other compounds like carnosic acid and rosmarinic acid, has been studied for its potential anticancer effects. Research suggests that ursolic acid can inhibit tumor growth and metastasis by various mechanisms, such as:
- Inducing apoptosis (programmed cell death) in cancer cells.
- Inhibiting angiogenesis, which is the formation of new blood vessels that tumors need to grow4.
- Modulating signaling pathways involved in cancer cell proliferation and survival.
Sulforaphane
Sulforaphane is a naturally occurring compound found in cruciferous vegetables like broccoli, Brussels sprouts, and kale. It is an isothiocyanate, which is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane during the process of chopping or chewing these vegetables.
Anticancer Properties of Sulforaphane
Sulforaphane has garnered significant attention for its potential anticancer properties. Here are some key mechanisms through which it may help in cancer prevention and treatment:
- Induction of Detoxification Enzymes: Sulforaphane activates phase II detoxification enzymes, which help in neutralizing carcinogens and protecting cells from oxidative damage.
- Epigenetic Modulation: It can alter gene expression by modifying epigenetic markers, which can suppress tumor growth and proliferation.
- Apoptosis Induction: Sulforaphane promotes apoptosis (programmed cell death) in cancer cells, thereby inhibiting their growth.
- Inhibition of Cell Cycle Progression: It can halt the cell cycle in cancer cells, preventing them from multiplying.
- Suppression of Tumor Stem Cells: Sulforaphane targets cancer stem cells, which are often responsible for cancer recurrence and resistance to conventional therapies.
- Anti-inflammatory Effects: It reduces inflammation, which is a known risk factor for the development and progression of cancer.
Apigenin
Apigenin is a naturally occurring flavonoid found in many fruits, vegetables, and herbs, such as parsley, chamomile, and celery. It is known for its various health benefits, including anti-inflammatory, antioxidant, and antibacterial properties.
When it comes to its anticancer properties, apigenin has shown promising results in both in vitro (test tube) and in vivo (animal) studies. Here are some key anticancer mechanisms of apigenin:
- Inducing Apoptosis: Apigenin can trigger programmed cell death (apoptosis) in cancer cells, helping to eliminate them from the body.
- Cell Cycle Arrest: It can halt the cell cycle in cancer cells, preventing them from multiplying.
- Autophagy: Apigenin promotes autophagy, a process where cells degrade and recycle their own components, which can lead to the death of cancer cells.
- Inhibiting Migration and Invasion: It can suppress the ability of cancer cells to migrate and invade other tissues, which is crucial in preventing metastasis.
- Modulating Signaling Pathways: Apigenin affects various cell signaling pathways involved in cancer progression, such as the PI3K/AKT, MAPK/ERK, JAK/STAT, NF-κB, and Wnt/β-catenin pathways.
- Immune Response Stimulation: It can enhance the body’s immune response against cancer cells.
Apigenin,Apigenin powder,Apigenin extract,Celery extract,Chamomile extract CAS:520-36-5 (extractspowder.com)
Antrodia camphorata
Antrodia camphorata, also known as Niu-chang-chih or Chang-chih, is a medicinal mushroom native to Taiwan. It has been traditionally used for its various health benefits, including antioxidant, anti-inflammatory, and hepatoprotective properties.
Regarding its anti-cancer properties, research indicates that Antrodia camphorata extract contains bioactive compounds such as ergostane-type triterpenoids (antcins) and meroterpenoids (antroquinonols), which have shown potential anti-cancer activities. These compounds have been found to inhibit the growth of cancer cells and induce apoptosis (programmed cell death) in various cancer cell lines. Additionally, studies suggest that the extract can protect DNA from oxidative damage and reduce mutagenesis, which are crucial factors in cancer prevention.
While these findings are promising, it’s important to note that most of the research has been conducted in vitro (in the lab) or in animal models. Clinical trials in humans are still limited, so more research is needed to fully understand its efficacy and safety in cancer treatment.
Naringin
Naringin is a flavonoid primarily found in citrus fruits like grapefruits and oranges. It is known for its bitter taste and various health benefits, including antioxidant, anti-inflammatory, and anticancer properties.
Regarding its anticancer properties, naringin has shown promising results in several studies. It can inhibit the proliferation of tumor cells by blocking the cell cycle, induce apoptosis (programmed cell death), and prevent metastasis (spread of cancer cells) and invasion. Additionally, naringin can enhance the sensitivity of cancer cells to chemotherapy drugs and reduce adverse reactions to chemotherapy. These effects make it a potential supplementary remedy in cancer treatment
Camptothecin
Camptothecin (CPT) is a natural compound originally isolated from the bark and stem of the tree Camptotheca acuminata, also known as the “Happy Tree,” which is native to China. It is known for its potent anti-cancer properties, primarily due to its ability to inhibit the enzyme topoisomerase I.
Topoisomerase I is crucial for DNA replication and transcription. By inhibiting this enzyme, camptothecin causes DNA damage, leading to cell death, which is particularly effective against rapidly dividing cancer cells. Camptothecin has shown significant anti-tumor activity against a variety of cancers, including breast, ovarian, colon, lung, and stomach cancers.
However, camptothecin itself has low solubility and can cause adverse side effects. To address these issues, several derivatives of camptothecin, such as topotecan and irinotecan, have been developed and are used in cancer chemotherapy.
Look into adverse side effects carefully before ordering!!!!!
Luteolin
Luteolin is a naturally occurring flavonoid found in various fruits, vegetables, and herbs. It is known for its anti-inflammatory and antioxidant properties.
Regarding its anti-cancer properties, luteolin has shown promising potential. Research indicates that luteolin can inhibit the proliferation of cancer cells, induce cell cycle arrest, and promote apoptosis (programmed cell death) in cancer cells. It also has the ability to inhibit angiogenesis (the formation of new blood vessels that feed tumors) and metastasis (the spread of cancer to other parts of the body).
Cnidium monnieri
Cnidium monnieri, also known as She Chuang Zi, is a traditional Chinese medicinal herb. The extract from this plant contains several active compounds, with osthole being one of the most studied. Osthole has shown a range of pharmacological activities, including anticancer properties.
Research indicates that osthole can inhibit cancer cell proliferation, induce apoptosis (programmed cell death), and prevent the invasion and migration of cancer cells. It also appears to enhance the effectiveness of chemotherapy drugs and reverse multidrug resistance in cancer cells. Additionally, studies have highlighted its potential in treating specific cancers, such as hepatocellular carcinoma (a type of liver cancer), by affecting various biological pathways.
cnidium monnieri extracto imperatorin 98%,imperatorin cancer,imperatorin powder 482-44-0 (extractspowder.com)
Blackseed Oil (Nigella sativa)*
Black seed oil is derived from the seeds of the Nigella sativa plant, also known as black cumin. It has been used for centuries in traditional medicine for its various health benefits.
Regarding its anticancer properties, research suggests that black seed oil, particularly its active compound thymoquinone, may have potential in fighting cancer. Studies have shown that thymoquinone can inhibit the proliferation of cancer cells and even induce apoptosis (programmed cell death) in certain types of cancer cells12. Additionally, it may enhance the effects of chemotherapy and radiation treatments3.
Caffeic Acid*
Caffeic acid has shown potential anticancer effects through several mechanisms:
- Antioxidant Activity: It helps neutralize free radicals, reducing oxidative stress which can lead to cancer.
- Anti-inflammatory Effects: By reducing inflammation, it can lower the risk of cancer development.
- Inhibition of Cancer Cell Growth: Studies have shown that caffeic acid can inhibit the growth of various cancer cells and enhance the effectiveness of chemotherapy and radiation therapy.
Find a source
Coq10*
Coenzyme Q10 (CoQ10) is a compound naturally produced by the body. It plays a crucial role in generating energy within cells and acts as an antioxidant, protecting cells from damage caused by free radicals1. CoQ10 is found in high concentrations in organs with high energy demands, such as the heart, liver, kidneys, and pancreas.
Regarding its anticancer properties, research is still ongoing. Some studies suggest that CoQ10 may help reduce oxidative stress, which is linked to cancer development. Additionally, low levels of CoQ10 have been observed in patients with certain types of cancer. However, clinical trials in humans have been limited and have not conclusively proven its effectiveness in treating cancer.
DCA (Dichloroacetate)*
Dichloroacetate (DCA) is a small molecule that has gained attention for its potential as an anticancer agent. It works primarily by inhibiting an enzyme called pyruvate dehydrogenase kinase (PDK). This inhibition leads to the reactivation of the pyruvate dehydrogenase complex, which shifts the metabolism of cancer cells from glycolysis (a less efficient form of energy production) back to glucose oxidation (a more efficient form).
Here are some key anticancer properties of DCA:
- Metabolic Reprogramming: By inhibiting PDK, DCA forces cancer cells to switch from glycolysis to glucose oxidation, which can reduce the growth and survival of cancer cells.
- Selective Targeting: DCA tends to affect cancer cells more than normal cells because cancer cells rely heavily on glycolysis for energy production, a phenomenon known as the Warburg effect.
- Synergistic Effects: DCA has been shown to work synergistically with other anticancer agents, enhancing their effectiveness and potentially reducing the required doses and side effects.
- Induction of Apoptosis: DCA can induce apoptosis (programmed cell death) in cancer cells by increasing the production of reactive oxygen species (ROS) and disrupting mitochondrial function.
Find a source
Dimethyl Sulfoxide (DMSO)*
Dimethyl Sulfoxide (DMSO) is a chemical compound with a variety of uses. It is known for its ability to penetrate the skin and other biological membranes, which makes it useful in medical and industrial applications. DMSO is often used as a topical analgesic, anti-inflammatory, and antioxidant. It is also used to enhance the absorption of other medications through the skin.
Regarding its availability, DMSO can be purchased without a prescription in many places, typically in gel or cream form. It is often found in health food stores, available by mail order, and online. However, it’s important to note that while it is available over-the-counter, the quality and concentration can vary, and some products may contain impurities.
Find out how this would be used...
Doxycycline*
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline class. It’s commonly used to treat bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted infections.
Interestingly, doxycycline has also shown potential anticancer properties. Here are some key points:
- Inhibition of Cancer Stem Cells: Doxycycline can inhibit cancer stem cell-like properties in pancreatic cancer by targeting the PAR1/FAK/PI3K/AKT pathway. This inhibition can reduce tumor growth and enhance the effectiveness of other treatments like 5-fluorouracil.
- Anti-inflammatory and Anti-tumor Activity: Doxycycline exhibits anti-inflammatory and anti-tumor activities. It has been tested in clinical trials for its chemotherapeutic potential in various cancers, including colon cancer.
- Suppression of Tumor Progression: Doxycycline can attenuate cancer cell growth by suppressing the NLRP3 inflammasome, which is involved in inflammation and tumor progression.
Not available without prescription in the UK.
Frankincense*
Frankincense, derived from the resin of the Boswellia serrata tree, has been used for centuries in traditional medicine and religious rituals. It is known for its anti-inflammatory, antimicrobial, and anticancer properties.
Anticancer Properties of Frankincense
- Boswellic Acids: The primary active compounds in frankincense are boswellic acids. These acids have shown potential in inhibiting the growth of cancer cells and preventing them from spreading. They work by inducing apoptosis (programmed cell death) in cancer cells while sparing healthy cells.
- Anti-inflammatory Effects: Chronic inflammation is a known risk factor for cancer. Frankincense’s anti-inflammatory properties help reduce inflammation, which can lower the risk of cancer development.
- Inhibition of Tumor Growth: Studies have indicated that frankincense can inhibit the growth of various types of cancer cells, including breast, prostate, and pancreatic cancers. It does this by interfering with the cancer cells’ ability to form new blood vessels, which are necessary for tumor growth.
- DNA Protection: Boswellic acids may also prevent the formation of DNA in cancerous cells, thereby limiting their ability to grow and spread.
Hesperidin*
Hesperidin is a flavonoid glycoside primarily found in citrus fruits like oranges, lemons, and tangerines. It is known for its antioxidant and anti-inflammatory properties, which contribute to various health benefits.
Regarding its anticancer benefits, hesperidin has shown promising potential in several areas:
- Regulation of Cell Signaling: Hesperidin can modulate various cell signaling molecules, which play a crucial role in cancer development and progression.
- Induction of Apoptosis: It promotes apoptosis (programmed cell death) in cancer cells, helping to reduce tumor growth.
- Inhibition of Angiogenesis: Hesperidin can inhibit the formation of new blood vessels (angiogenesis) that tumors need to grow.
- Cell Cycle Arrest: It can cause cell cycle arrest, preventing cancer cells from multiplying.
- Anti-inflammatory Effects: By reducing inflammation, hesperidin helps create an environment less conducive to cancer development.
These mechanisms collectively contribute to hesperidin’s potential as an anticancer agent.
sweet orange peel extract,tangerine peel extract,Hesperidin,Nobiletin Cas520-26-3,478-01-3 (extractspowder.com)
Lugol’s Iodine*
Lugol’s Iodine is a solution of iodine and potassium iodide in water. It’s commonly used as a disinfectant and antiseptic, and in medical diagnostics, particularly for thyroid function tests.
Regarding its anticancer properties, iodine, including Lugol’s Iodine, has shown several potential benefits:
- Antioxidant and Immunomodulator: Iodine acts as an antioxidant and helps modulate the immune system, reducing inflammation and oxidative stress.
- Apoptosis Induction: It can induce apoptosis (programmed cell death) in cancer cells, which is crucial for preventing the proliferation of malignant cells.
- Reduction of Cancer Stem Cell Markers: Iodine has been found to reduce markers associated with cancer stem cells, which are often responsible for cancer recurrence and resistance to treatment.
- Enhancement of p53 Function: Iodine can upregulate the p53 gene, known as the “guardian of the genome,” which plays a critical role in suppressing tumors.
- Chemoresistance Reduction: It also helps reduce chemoresistance, making cancer cells more susceptible to chemotherapy.
Don't make it (very dangerous), find a recommended brand.
MCT Oil*
Keto diet - Helps stay in Ketosis. Take in the morning with coffee.
Mistletoe*
Mistletoe, particularly the European mistletoe (Viscum album), contains several biologically active compounds that have shown potential anticancer properties. The primary active compounds are lectins (ML-1, ML-2, ML-3, and ML-4), which have been found to stimulate the immune system and directly induce the death of cancer cells.
Additionally, mistletoe extracts can modulate the immune response, increasing the activity of white blood cells and natural killer (NK) cells, which are crucial for targeting and destroying cancer cells. These extracts are often used as an adjuvant therapy in Europe, meaning they are used alongside traditional cancer treatments like chemotherapy to enhance overall treatment outcomes.
Omega-3 Fatty Acids*
Omega-3 fatty acids have shown several potential benefits in the context of cancer treatment and prevention:
- Anti-inflammatory Properties: Omega-3s are known for their anti-inflammatory effects, which can help reduce inflammation associated with cancer and its treatments.
- Improved Chemotherapy Tolerance: Some studies suggest that omega-3s may enhance the efficacy and tolerability of chemotherapy drugs, potentially improving patient outcomes.
- Reduced Risk of Recurrence: Regular consumption of omega-3s may lower the risk of cancer recurrence by reducing inflammation and supporting overall health.
- Support for Heart Health: Cancer treatments like chemotherapy and radiation can have adverse effects on heart health. Omega-3s can help mitigate these effects by lowering cholesterol and protecting the heart.
- Potential Tumor Reduction: Research indicates that omega-3s might play a role in reducing tumor growth, particularly in breast and prostate cancers.
This is EPA concentrated, find out if DHA is as important and whether it is available. See how prices compare to off the shelf fish oil supplements.
Oroxylum indicum*
Oroxylum indicum, also known as the Indian trumpet flower or Shyonaka, is a deciduous tree native to the Indian subcontinent and Southeast Asia. It belongs to the Bignoniaceae family and is valued for its medicinal properties in traditional medicine systems like Ayurveda.
Anticancer Benefits
Oroxylum indicum has shown promising anticancer properties, particularly due to its rich flavonoid content. Here are some key findings:
- Hepatocellular Carcinoma (HCC): Studies have demonstrated that Oroxylum indicum can inhibit the migration, invasion, and neovascularization of HepG2 cells (a type of liver cancer cell). It achieves this by regulating apoptosis-related genes and blocking the VEGF signaling pathway.
- Apoptosis Induction: The tree’s extracts have been found to upregulate the expression of pro-apoptotic genes like Bax, P53, and Caspase-3, while downregulating anti-apoptotic genes such as Bcl-2 and MDM2. This suggests that Oroxylum indicum can induce apoptosis (programmed cell death) in cancer cells.
- Other Cancer Types: Oroxylum indicum and its major phytocompound, baicalein, have shown antiproliferative activity against various cancer cell lines, including murine melanoma, human colon carcinoma, leukemia, and HeLa cells.
These findings highlight the potential of Oroxylum indicum as a natural therapeutic agent in cancer treatment.
Oroxylum indicum contains several bioactive compounds, primarily from the flavonoid group. Here are some of the key active compounds:
- Baicalein: This is one of the most abundant and well-studied compounds in Oroxylum indicum. It has shown various therapeutic potentials, including anticancer, anti-inflammatory, and antioxidant properties.
- Chrysin: Another important flavonoid, chrysin is known for its anti-inflammatory and anticancer activities.
- Oroxylin A: This compound has been studied for its neuroprotective and anticancer effects.
- Scutellarin: Known for its cardiovascular benefits, scutellarin also exhibits antioxidant and anti-inflammatory properties.
- Ellagic Acid: This compound has antioxidant properties and is being studied for its potential anticancer effects.
breviscapine/scutellarin/erigeron breviscapus/breviscapinun Cas.No.:116122-36-2 (extractspowder.com)
Sodium Bicarbonate*
Sodium bicarbonate, commonly known as baking soda, is a white crystalline powder that is often used in baking, cleaning, and even as an antacid to relieve heartburn. Chemically, it is a salt composed of sodium ions and bicarbonate ions.
Regarding its anticancer benefits, the topic is quite complex and still under research. Here are some key points:
- Alkalizing Effect: Sodium bicarbonate can neutralize acids, which has led to the hypothesis that it might help in creating a less acidic environment around tumors. Cancer cells often thrive in acidic conditions, so reducing acidity might inhibit their growth.
- Complementary Treatment: Some studies suggest that sodium bicarbonate might make cancer treatments more effective. For example, it could help in making drug-resistant tumors more susceptible to chemotherapy by neutralizing the acidic environment that allows cancer cells to hide and become dormant.
- Research Findings: Research has shown that sodium bicarbonate can increase the pH of tumors and slow the formation of metastases in certain cancer models, such as metastatic breast cancer in mice. However, these findings are preliminary and primarily based on animal studies.
- Immune Response: There is also evidence suggesting that bicarbonate ions can influence immune responses, potentially regulating the activity of immune cells involved in cancer development.
Bromelain
Anticancer Properties of Bromelain
- Inhibition of Tumor Growth: Bromelain has been shown to inhibit the proliferation of tumor cells and induce apoptosis (programmed cell death) in various cancer cell lines.
- Anti-Metastatic Effects: It can interfere with the metastatic process by cleaving molecules like CD44, which are involved in the initial steps of metastasis.
- Immunomodulatory Effects: Bromelain enhances the immune system’s ability to fight cancer by modulating immune responses.
- Anti-Inflammatory Properties: By reducing inflammation, bromelain can create a less favorable environment for cancer cells to thrive.
General guidelines suggest:
- For general health benefits: 200-400 mg per day, taken in divided doses.
- For anti-inflammatory effects: 500-2,000 mg per day, taken in divided doses.
Properties could be enhanced by N-acetylcysteine (NAC)
N-acetylcysteine (NAC)
- Antioxidant Activity: NAC helps reduce oxidative stress by scavenging free radicals, which can prevent DNA damage and reduce the risk of mutations that may lead to cancer.
- Modulation of Cell Survival and Apoptosis: NAC can influence cell survival pathways and promote apoptosis (programmed cell death) in cancer cells. This can help inhibit the growth and proliferation of cancer cells.
- Inhibition of Metastasis: NAC has been found to lower reactive oxygen species (ROS) levels in cancer cells, which can reduce their ability to metastasize or spread to other parts of the body.
- Combination Therapy: Studies have shown that NAC, when used in combination with other treatments like bromelain, can significantly inhibit the proliferation and survival of cancer cells, particularly in gastrointestinal cancers.
- Anti-inflammatory and Immunological Effects: NAC has anti-inflammatory properties and can modulate the immune response, which may contribute to its anticancer effects.
This is what I have so far.
My next phase of research will be towards which of these compounds are more effective against bowel cancer and the dosages.
From what I have found so far, the doses are going to be much harder to figure out.
I'm still working my way through the classroom content, so hopefully, i'll find more guidance in there.
Let me know if you find this helpful.
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An update on my research - so far
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