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Is there anything in blocking Lactate and succinct anti-porters? MCT1, MCT2 and OAT lower he acidic Tumour microenvironment? Yes ketone uptake will also be lowered but MCT4 is still there. We spend our time trying to find inhibitiors of glucose and glutamine but what if we could jam up the cell with lactate and succinate? Would that send the cell towards apoptosis due to the ph drop?
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