PT-141 (bremelanotide) is a melanocortin receptor agonist that works centrally in the brainโnot like Viagra.
FDA-Approved Dosing (HSDD in women):
๐น 1.75 mg subQ
๐น ~45 min before activity
๐น Max 1x/24 hrs | Max 8x/month
Research/Off-Label Tiers:
๐ Starting: 0.5 mg once weekly
๐ Maintenance: 1โ2 mg once weekly
๐ Max: 2 mg per dose
Dose-Response Data:
- Men: Significant effects at >1.0 mg subQ
- Women: 1.25โ1.75 mg showed best response
Common Sides: Nausea (~40%), flushing, headache, BP spikes
Contraindications: Uncontrolled HTN, CVD, pregnancy
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