10d • General discussion
Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking
DISCLAIMER
Read First
This guide is for educational purposes only. Peptides are not approved drugs in most countries. Everything here is off label and experimental. Do your own research. You are responsible for your own choices. This is not medical advice.
Age Note
Several peptides are specifically marked as inappropriate for users under 18-20 years old due to ongoing hormonal and neural development. These warnings are clearly flagged throughout.
Sources
Evidence grades reflect actual human clinical trial data, animal studies, and in vitro research. Grade A = multiple human RCTs. Grade B = some human data. Grade C = animal/in vitro only.
PEPTIDES COVERED IN THIS THREAD
1. Semax — ACTH(4-7) Analogue — Nootropic
2. Selank — Tuftsin Analogue — Anxiolytic & Cognitive
3. GHK-Cu — Copper Peptide — Skin & Collagen
4. AHK-Cu — Copper Peptide — Hair Growth
5. Melanotan-1 (MT-1) — MC1R Agonist — Tanning
6. BPC-157 — Body Protection Compound — Healing
7. TB-500 — Thymosin Beta-4 — Recovery & Flexibility
8. DSIP — Delta Sleep-Inducing Peptide — Sleep Architecture
9. SS-31 (Elamipretide) — Mitochondria-Targeting Peptide — Energy & Cardioprotection
10. MOTS-C — Mitochondrial-Derived Peptide — Metabolic
11. 5-amino-1MQ — CD38 Inhibitor — NAD+ Preservation
12. Thymosin Alpha-1 — Immune Modulator — Immune Enhancement
13. KPV — Anti-Inflammatory Tripeptide — Gut & Skin
14. Cerebrolysin — Neuropeptide Mix — Cognitive & Neuroprotection
15. Snap-8 — Neuropeptide — Anti-Wrinkle Topical
16. Pinealon — Pineal Peptide — Neuroprotection & Circadian
17. Epithalon (Epitalon) — Tetrapeptide — Telomere (Age 40+ Only)
18. Ipamorelin — GHRP — GH Secretagogue (Age 20+ Optimal)
19. NAD+ — NAD+ Precursors — Mitochondrial (Age 35+ Only)
PEPTIDES NOT RECOMMENDED FOR THIS CONTEXT
Do Not Use — Reasons Explained
Semaglutide / Tirzepatide / Retatrutide / Cagrilintide
If you can't get your body fat down to 10% at least once in your life, what can you actually do?
I use Tirzepatide myself
IGF-1 LR3 (Used it myself)
Highly anabolic IGF-1 analogue. Promotes growth in ALL tissues including potential tumor cells. Open growth plates at 17-18 make this particularly concerning. Hypoglycemia risk. Not appropriate under 21+.
Dermorphin
Opioid peptide — 50x more potent than morphine. Extremely high addiction potential. Not appropriate for any looksmaxxing or performance context. High risk of dependence, respiratory depression, death in overdose.
Adipotide
Experimental peptide targeting ANXA2/PROHIBITIN on fat cell vasculature. Causes kidney toxicity in primate studies. Never cleared for human use. Avoid entirely.
Oxytocin
Half-life 3-5 minutes IV. Intranasal slightly longer. No meaningful persistent anxiolytic effect for social situations. Better alternatives available (Etifoxine, Selank, Pregab).
PT-141 (Bremelanotide)
MC3R/MC4R agonist for sexual dysfunction. More systemic side effects than MT-1. Nausea, blood pressure effects. Not a looksmaxxing compound.
STACKING GUIDE
Recommended Stacks by Goal
Cognitive Peak
Semax (1mg/day IN) + Citicoline (250mg/day oral) + Selank (500mcg situational). Semax → focus/BDNF, Citicoline → ACh, Selank → anxiety control.
Skin & PIE
GHK-Cu (2mg subcut EOD) + Tretinoin (topical) + Azelaic Acid 20% (topical) + Niacinamide 10% (topical). Best-evidenced combination.
Post-Surgery
BPC-157 (500mcg/day) + TB-500 (2mg 2×/week) + GHK-Cu (500mcg/day) + KPV (1mg/day). 8-week protocol.
Healing & Recovery
BPC-157 + TB-500 combo vial (BBG or KLOW80 mix). Most cost-effective option. KLOW80 adds KPV for anti-inflammatory.
Sleep Quality
DSIP (200mcg subcut pre-bed) + Ipamorelin (100mcg pre-bed). Synergistic GH pulse + deep sleep architecture.
Mitochondrial Stack
SS-31 (2mg/day) + MOTS-C (5mg 3×/week). Age 30+ optimal. Limited benefit at 18.
Immune Support
Thymosin Alpha-1 (1mg 2×/week) for 4-6 weeks during illness, intense training periods, or post-surgery.
Anxiolysis (Daily)
Selank (400-600mcg/day, cycled 14/14). No dependence, no sedation. Best daily option.
Anxiolysis (Events)
Etifoxine 50mg → Pregabalin 75-150mg (reserve for important only). Never two GABAergics same day.
CRITICAL INTERACTIONS
READ BEFORE STACKING
ABSOLUTE
NEVER: Selank + Etifoxine + Pregabalin same day. Three GABAergics = CNS depression risk.
ABSOLUTE
NEVER: MT-1 + MT-2 simultaneously. Receptor overlap, unpredictable systemic effects.
AVOID
Ipamorelin/CJC-1295 on fasted training days — hypoglycemia risk.
AVOID
Semax + Modafinil daily — both dopaminergic. Limit to exam days only.
SEPARATE
GHK-Cu and Zinc: pause zinc during GHK-Cu cycle. Competition for transporters.
SEPARATE
MT-1 and GHK-Cu injections: different anatomical sites same evening.
NOTE
BPC-157 / TB-500 / GHK-Cu vendor combo mixes (BBG, KLOW80) can be drawn from same vial — convenient and cost-effective.
RECONSTITUTION QUICK REFERENCE
Standard Dilutions
Semax 40mg4ml BAC water → 10mg/ml → 1mg dose = 0.1ml
Selank 5mg1ml BAC water → 5mg/ml → 250mcg = 0.05ml
GHK-Cu 2mg1ml BAC water (or PBS) → 2mg/ml → 2mg = 1ml
GHK-Cu 50mg (bulk)25ml BAC water → 2mg/ml → 2mg = 1ml
MT-1 10mg1ml BAC water → 10mg/ml → 500mcg = 0.05ml
BPC-157 5mg1ml BAC water → 5mg/ml → 250mcg = 0.05ml
TB-500 5mg1ml BAC water → 5mg/ml → 2mg = 0.4ml
Ipamorelin 5mg1ml BAC water → 5mg/ml → 100mcg = 0.02ml
DSIP 5mg1ml BAC water → 5mg/ml → 200mcg = 0.04ml
Epitalon 10mg2ml BAC water → 5mg/ml → 5mg = 1ml
Thymosin Alpha-1 5mg1ml BAC water → 5mg/ml → 1mg = 0.2ml
KPV 10mg1ml BAC water → 10mg/ml → 1mg = 0.1ml (or oral)
PBS vs BAC WaterUse PBS for copper peptides (GHK-Cu, AHK-Cu) — better copper stability. BAC water for all others.
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Complete Guide to Peptide Protocols — Dosing, Evidence & Stacking
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