If you are looking to write a GUI application with LLM assistance, I have had a good experience with:
electron-vite
react 19 + tailwind 4 (v4 is a vite plugin, which helps) + shadCN
playwrite (using electron's experiemental playwrite support + playwrite MCP server)
This has been much smoother than my failed Tauri attempt, and my attempts to use anything browser-based while working with the local filesystem. Hopefully this is useful to someone.