If you’ve heard HGH pitched for belly fat, muscle loss, or getting your energy back after 40, here’s the question I’d ask first: Has a growth hormone deficiency actually been diagnosed? What is HGH? Human growth hormone, or HGH, is a protein hormone made by your pituitary gland. It helps children grow and continues to play a role in bone health, body composition, and metabolism in adults. Some of its effects are carried out through another hormone called IGF-1. Somatropin is the prescription form of recombinant human growth hormone. Who is it for? ✅ Adults with confirmed growth hormone deficiency. This can happen after pituitary disease, surgery, or radiation, or when a deficiency diagnosed in childhood persists into adulthood. For adults who qualify, treatment can improve body composition, exercise capacity, and quality of life. Benefits vary, and treatment requires follow-up. ✅ Children with certain diagnosed growth conditions. Depending on the specific somatropin product, approved uses can include growth hormone deficiency, Turner syndrome, or persistent growth failure after being born small for gestational age. A pediatric endocrinologist evaluates the cause of poor growth and whether treatment fits. How do doctors know if you’re deficient? Growth hormone is released in pulses, so one random HGH blood test can’t diagnose a deficiency. An endocrinologist considers your medical history and IGF-1 result and usually uses a stimulation test to see how much growth hormone your body can release. A low IGF-1 result alone usually isn’t enough. Who should avoid it? - People looking for a menopause, weight loss, bodybuilding, or anti-aging treatment. Those goals don’t establish a growth hormone deficiency. A review of trials in healthy older adults found small changes in body composition alongside more adverse effects. - People with active cancer, acute critical illness after major surgery or trauma, or acute respiratory failure.These are listed contraindications. So are active proliferative or severe nonproliferative diabetic retinopathy. - Children whose growth plates have closed, when the goal is to increase height. This is separate from evaluating whether someone needs hormone replacement as an adult. - Children with Prader-Willi syndrome who have severe obesity, upper airway obstruction or sleep apnea, or severe respiratory impairment. Somatropin labeling includes specific contraindications for these children.