The Lp(a) story continues to be one of the most exciting developments in preventive cardiology, and this week brought fresh pipeline context: • Muvalaplin (Eli Lilly) — oral Lp(a)-lowering agent, Phase 2 data complete, Phase 3 underway at UC Health and other centers • Lepodisiran (诺华/Novartis) — siRNA agent, single injection showing reductions of ~90%+ in Phase 1/2; ACCLAIM-Lp(a) trial active • Olpasiran (安进/Amgen) — siRNA, similar efficacy profile • Pelacarsen (Ionis/AstraZeneca) — ASO agent, earliest in development The HORIZON trial — first dedicated cardiovascular outcomes trial for an Lp(a)-lowering agent — is expected to report before end of 2026. This is the data that will tell us whether lowering Lp(a) actually reduces events the way LDL lowering does. If HORIZON is positive, Lp(a) screening moves from "interesting but untreatable" to "actionable cardiovascular risk factor" — a massive shift in preventive cardiology practice. Source: UCHealth Today, August 4 · [Family Heart Foundation / ACC/AHA 2026 Guideline]