Does Vitamin A cause toxicity?
Unlike the name indicates, it is not a single compound. Instead its a blanket term for a group of active unsaturated molecules including: - Retinoids - Retinol - Retinaldehyde - Retinoic acid - Provitamin A Carotenoids - Beta-carotene - Alpha-carotene - Gamma-carotene - Beta-cryptoxanthin - Alpha-cryptoxanthin A provitamin is a substance that can be converted into a vitamin within the body. It is a precursor to the active form of a vitamin and usually requires a metabolic conversion before it can fulfil the functions of the vitamin. In this example, carotenoids are converted into active vitamin A (retinol) in the body. Beta-carotene is the most well-known and studied provitamin A carotenoid. The recommended daily intake for vitamin A for a normal sized male is about 900-3000 μg/day of retinal, retinol, or retinoic acid, or about 12-24 times that of carotenoids, since they have a significantly lower bioavailability in the human body and are also poorer sources of the active vitamin A. What does Ray Peat say about Vitamin A? "I found that I had an extremely high vitamin A requirement, increased by stress or bright light, and that it was related to thyroid function. Usually, thyroid and vitamin A are the supplements that stop acne. I avoid carotene, because it blocks thyroid and steroid production, and very large, excessive, amounts of vitamin A, retinol, can do the same. I use halibut liver oil-derived vitamin A, or retinyl palmitate. The toxic effects of extremely big doses, such as 500,000 to a million i.u., seem to be from either oxidative processes (rancidity) that are prevented by adequate vitamin E, or by antithyroid effects. I found that when my need for vitamin A began to decrease I tended to accumulate carotene in my calluses; that happens when the thyroid function is lower, reducing the need for vitamin A. Since you are eating foods with carotene, the calluses on your palms or soles should serve as an indicator of when your tissues are saturated with vitamin A. About 100 i.u. of vitamin E would help to keep the vitamin A from being wasted by oxidation, and possibly could reduce your requirement for it.”