A 29 y/o female patient presents with heavy menstrual bleeding, frequent nosebleeds, and prolonged bleeding after a dental extraction. Which disorder is most likely?

At the University of Miami game you come across a 62 year old male who got hit in the chest by an angry fan swinging a football helmet. A trauma patient with chest pain, JVD, arrhythmias, and hypotension MOST likely has:

Why TXA is generally NOT used in variceal hemorrhage 1. Variceal bleeding is a pressure problem, not a clotting problem - Esophageal varices bleed due to portal hypertension - The bleeding source is high-pressure venous flow - TXA stabilizes clots, but it does not reduce portal pressure - Without lowering pressure, clots are easily displaced and bleeding continues 2. Large clinical trials showed no benefit and possible harm In major GI bleeding studies (including variceal bleeds): - No reduction in mortality - No reduction in rebleeding - Higher risk of thromboembolic events (DVT, PE) - Higher risk of seizures at higher doses As a result, modern GI and hepatology guidelines do not recommend TXA for routine upper GI or variceal bleeding.

Unlike peritoneal dialysis, hemodialysis:

Compared to peritonitis, hepatitis would more likely present initially with: