Most of your favorite peptides probably have something to do with weight loss or body composition. That's part of why ARA-290 gets overlooked. It's ultimate purpose is for repair and anti-inflammation. It's a synthetic peptide derived from erythropoietin (EPO) but without the cardiovascular risks. They essentially isolated the repair components that help with neuroprotection and tissue-protection while getting rid of the part that stimulated red blood cell production. ARA-290 binds to something called the innate repair receptor (IRR). These receptors are formed and appear on the outside of localized areas where severe metabolic stress, low oxygen, or tissue injury exists. This is basically a receptor that can be targeted to create a shift in the local environment that may be pro-inflammatory and tissue-damaging and turn it around into a healing and tissue repair environment by reducing cytokine production and enhancing some tissue repair processes. If you read the Immune System course, cytokines are your immune system's inflammatory signaling molecules that are driving inflammation for various reasons throughout the body. In animals, they actually observed long-term relief after sciatic nerve injury, and that relief came FAST. In humans, they've looked at it for small fiber neuropathy. Small fiber neuropathy is the nerve damage that can cause burning, tingling, and pain. In the sarcoidosis group, it significantly helped with neuropathic and autonomic symptoms and 28-days of treatment was actually able to initiate regrowth of small nerve fibers in the cornea. The same thing happened in the type 2 diabetes patients, but they also had a better metabolic profile (so pay attention to that side of things if using). In all populations, there were really no significant adverse effects. From personal experience, I can tell you that within 4 days, my sciatic pain was almost completely gone. Before ARA-290, I was limping around half of the day. The reconstitution protocol is in the classroom over in the paid community as well because this one can be a bit tricky.

I posted this over in the paid community, but want to make sure everyone over here understands this! If you've ever used AOD, ARA, or a few others, you may have noticed gelling or clumping. There are a few peptides where you may need a solvent other than BAC in order to get them to reconstitute properly. These liquids are NOT interchangeable with each other. They will need one or the other. Acetic Acid: This has a LOWER pH number. The pH of the solution is around 2.75-3. Compounds that may need this: AOD-9604 (almost always), HGH Frag 176-191 (this is basically AOD by the way), Kisspeptin (sometimes, not always). Tesamorelin, CJC-1295, Sermorelin should NOT need this if you're using Hospira branded BAC water. Phosphate Buffered Saline or Sodium Bicarbonate Solution: These have a HIGHER pH number. Depending on which one, the pH is around 7-8. Compounds that may need this: ARA-290 (almost always), Thymosin Alpha-1 (sometimes). If you use the reconstitution cheat sheets, I tell you the appropriate solutions to use. I have a vendor working on getting the sodium bicarbonate solution in stock currently. I feel like it's important for you to understand the pH differences to understand that you can't use AA for a PBS-requiring compound and vice versa or it will take the pH in the wrong direction and probably make things worse.

What is the usual starting dose for tirz and what would be the next step up?

Anyone have experience with mt1 or mt2 nasal sprays? Trying to decide if I should do nasal or subq.