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12 contributions to Castore: Built to Adapt
Endometriosis and PCOS
My girlfriend has endometriosis and pcos. I am looking for any protocols or information that may lead to healing. She has been diagnosed with intersistal cystitis as well. If anyone has experience with things that have helped them or someone they know, please share.
1 like • 1d
She’s insulin resistant - my wife had this years ago - as they say in this space you gotta “live the life” - get on a glp maybe with a metformin and or jardiance or a berberine something like that - but change the lifestyle - eat at home fresh whole foods exercise cardio weight lift - check the thyroid - start with selenium and iodine check vitamin d - especially if there’s autoimmune which all goes hand in hand - get am sunlight quality sleep etc etc
WHY MIXING PEPTIDES IN THE SAME SYRINGE BREAKS THE RULES OF PHYSICS AND BIOLOGY
Peptides are often treated like supplements you can stack for convenience. One for repair, one for metabolism, one for inflammation. That mindset leads people to assume they can simply mix peptides in the same syringe and inject once. The problem is peptides are not pills. They are fragile, information-carrying molecules whose behavior is governed by physics, chemistry, and biology at the same time. A peptide is not just a chain of amino acids. In solution it exists as a three-dimensional structure held together by weak forces like hydrogen bonds, electrostatic interactions, and hydrophobic effects. These forces are highly sensitive to the environment. Small changes in pH, ionic strength, or solvent conditions can change the peptide’s shape, stability, and behavior. When a peptide is manufactured, it is stabilized in a very specific formulation. That formulation controls pH, charge, ion balance, and solubility so the peptide stays folded correctly and remains biologically active. When you mix two peptides together, you destroy that controlled environment and create a new, untested chemical system. One of the first things that goes wrong is charge balance. Peptides carry electrical charge depending on pH. That charge helps keep molecules from sticking to each other. Mixing peptides can shift pH just enough to reduce repulsion between molecules. When repulsion drops, attraction wins, and peptides begin to stick together. Ionic strength matters too. Mixing solutions often increases ion concentration, which compresses the electrical “buffer” that keeps peptides apart. This allows molecules to drift close enough for hydrophobic regions to interact. Water dislikes exposed hydrophobic surfaces, so peptides clump together to lower free energy. This is basic solution physics. Once aggregation starts, it accelerates. A few misfolded molecules form a nucleus, which seeds further aggregation. Early clumps may be invisible, but they still matter. They reduce the amount of active peptide, alter absorption, and change signaling behavior.
1 like • 4d
@Drew Wurst He stated if it’s already blended in the same vial its good - he is talking about 3 separate vials going into one syringe at the time
1 like • 3d
@Drew Wurst sounds like he responded by liking my response
Visomitin eye drops vendor
Good morning! Does anyone know of a trusted vendor for Visomitin eye drops? I tried Cosmic Nootropics but they are not currently shipping to the US.
0 likes • 5d
If for whatever reason it doesn’t work out lemme know
OpenAI launched ChatGPT Health!!
Hello Everyone 👋 - Some of you may know already. OpenAI launched ChatGPT Health!! It was built to answer health and wellness questions for consumers. My understanding is that it was beta tested by over 600 MD physicians in over 60 countries to ensure accuracy with results, etc... I know we all have used AI platforms to field many of our health questions, even for peptide questions. AI is transforming speed and breadth of accessibility to information; we desperately need this access in the healthcare industry so we are informed, know the right questions to ask, better understanding of our biologics and hold the physicians accountable for a more comprehensive, informative and collaborative prognosis. We pay good 💰, that is hard earned and it is after-tax dollars, to have a healthier, more active lifestyle. And our Healthcare system has failed us by prioritizing net profit over preventative care initiatives, holistic integrative options, fair - honest knowledge share. I will leave it there b/c I am getting riled up when it comes to this topic 😊 This will not be the first and only healthcare AI dB knowledge platform. You can bet many will create more. AI developments are moving at lightening speed. So, here is one of the links - Enjoy 💕https://help.openai.com/en/articles/20001036-what-is-chatgpt-health - 🫂🤗
1 like • 5d
Pcp’s are in danger of becoming extinct lol (in America)
Plantar fasciitis
What are different protocols for plantar fasciitis?? Thanks
2 likes • 12d
Blood flow issue with the big toe being jammed in narrow shoes - check out squat university on YouTube he’s good
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Tyme Peptide
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@john-farrell-1590
Z

Active 16m ago
Joined Dec 6, 2025
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