❇️ If you've been following the metabolic peptide space lately, you've probably seen 5-Amino-1MQ pop up more and more. It's not a traditional peptide — it's a small molecule — but it's earned its place in research circles for one very compelling reason: it targets an enzyme called NNMT, and the downstream effects are seriously interesting. ❇️So What Is NNMT, and Why Does It Matter? NNMT stands for Nicotinamide N-Methyltransferase — an enzyme that methylates nicotinamide (a form of vitamin B3), effectively pulling methyl groups away from the metabolic pool and reducing NAD+ availability. When NNMT is overactive (which it tends to be in obese and insulin-resistant individuals), it acts like a metabolic brake. You get lower NAD+, slower mitochondrial function, and a harder time burning fat. 👉🏼 5-Amino-1MQ blocks NNMT. That's its whole job — and by doing so, it lets NAD+ levels rise naturally. ❇️ What the Research Shows 🔸 Preclinical studies have highlighted some notable effects: ➡ Fat loss without caloric restriction: In mouse models, NNMT inhibition led to significant reductions in body fat, even without changes to diet. The mechanism appears tied to increased energy expenditure at the cellular level. ➡ NAD+ elevation: Higher NAD+ means more fuel for sirtuins (especially SIRT1) and improved mitochondrial efficiency — both linked to longevity and metabolic health. ➡ Muscle preservation: Unlike aggressive caloric deficits that chew through lean mass, NNMT inhibition appears to preferentially target adipose tissue. ➡ Improved insulin sensitivity: Early data suggests better glucose handling, which is particularly relevant for metabolic syndrome research. ❇️How It's Different From NAD+ Precursors: You might be thinking: "Why not just take NMN or NR?" Fair question. Those work by directly adding NAD+ precursors to the system. 5-Amino-1MQ works differently — it removes the enzyme that's draining NAD+ in the first place. Think of it less like adding water to a leaky bucket and more like patching the hole. Some researchers believe this makes it especially relevant for metabolically compromised models where NNMT is chronically upregulated.

❇️ Peptide and small molecule classification by location of origin and main activity: Immune modulating peptides: - Thymosin Beta 4 - TB4 Active Frag (ac-SDKP) - Vilon/Thymogen - BPC 157 - KVP - Thymosin Alpha - TB4 Active Frag (AGES) - Zn-Thymulin - DSIP - GHK-Cu - Cerebrolysin Pineal Gland Peptides: - Epitalon - Pinealon - DSIP - Testagen - Melatonin GI/Leaky Gut/IBD/Gut-brain Axis peptides: - BPC157 - TB4 Active Frag (ac-SDKP) - KPV - DSIP - GHK- Cu - LL-37 - Tuftsin - Livagen - Larazotide Brain Peptides: - Cerebrolysin - Semax - Selank - BPC 157 - TB4 Active Frag (ac-SDKP) - DSIP - KVP - Humanin - SS-31 - MOTS-C - 5-amino-1mq - GHK- Cu - PE 22-28 - P21 - Methylene Blue - ARA 290 - Cortexin - Dihexa Antimicrobial Peptides: - LL-37 - BPC157 - TB4 Active Frag (ac-SDKP) - KPV - GHK-Cu - Methylene Blue Mitochondrial Peptides: - MOTS-c - SS-31 - Humanin - 5-amino-1mq - BPC157 - TB4 Active Frag (ac-SDKP) - Small-humanin-like-peptides (SHLP) - DSIP - T3 - Melatonin - PQQ - MitoQ - Methylene Blue Rejuvenation/pain/anabolic/healing peptides: - BPC157 - TB4 Active Frag (ac-SDKP) - Epitalon - Pinealon - DSIP - AOD-9604 - GHK-Cu - KPV - Cerebrolysin - FOX 04-DRI - Follistatin - ACE-031 - ARA-290 - Cardiogen - Carnosine GHRH/GHRP: - Sermorelin, ipamorelin, tesamorelin, cjc-1295, hexarelin, ibutamoren (MK-677), etc. Sleep peptides/ anti- anxiety: - DSIP - Epitalon - Pinealon - Growth hormone - GHRH/GHRP - AOD - Selank - BPC 157 • ⁃ KVP

Tell us something you are looking forward to. I'm looking forward to celebrating Cinco de Mayo and Mother's Day! Do you have any particular research compound you want us to go in depth and get the dirt? WE are happy to oblige.