Appendicitis is characterized by pain and tenderness in the lower right quadrant, midway between the umbilicus and the crest of the ilium. Test Taking Strategy— Analyze to determine what information the question asks for, which is the anatomic location of the tenderness experienced by a client with appendicitis. Recall that the classic sign of appendicitis is pain when pressure is applied and then released over what is known as McBurney’s point, in the lower right quadrant. The phenomenon is known as rebound tenderness. Review the signs of appendicitis if you had difficulty answering this question.